铀在小鼠体内的分布及其影响因素的初步探讨

邓冰, 王和义, 蒋树斌, 马俊格. 铀在小鼠体内的分布及其影响因素的初步探讨[J]. 环境化学, 2011, 30(7): 1247-1252.
引用本文: 邓冰, 王和义, 蒋树斌, 马俊格. 铀在小鼠体内的分布及其影响因素的初步探讨[J]. 环境化学, 2011, 30(7): 1247-1252.
DENG Bing, WANG Heyi, JIANG Shubin, MA Junge. THE BIODISTRIBUTION OF URANIUM IN MICE[J]. Environmental Chemistry, 2011, 30(7): 1247-1252.
Citation: DENG Bing, WANG Heyi, JIANG Shubin, MA Junge. THE BIODISTRIBUTION OF URANIUM IN MICE[J]. Environmental Chemistry, 2011, 30(7): 1247-1252.

铀在小鼠体内的分布及其影响因素的初步探讨

  • 基金项目:

    中国工程物理研究院科学技术发展基金资助项目(2009B0301029).

THE BIODISTRIBUTION OF URANIUM IN MICE

  • Fund Project:
  • 摘要: 通过尾静脉注射给药方式研究UO22+ 在小鼠体内的分布,通过建立包含主要体液的金属离子、小分子配体及UO22+及其配合物的热力学函数的热力学平衡模型,采用数值模拟方法研究UO22+在体液中的形态.研究表明,给药后铀的重要沉积部位为骨骼、肾脏和肝脾脏,主要通过小鼠肾脏排泄.肝脾脏器中铀的浓度随时间变化有两个峰值.血液中铀的清除速度较快.计算机模拟表明,血浆内UO22+主要以带电荷的UO22+配位离子形式存在,血浆内UO22+形态与总铀浓度相关.UO22+能与PO43-等离子形成溶度积很高的固态物质,造成UO22+长期沉积在骨骼,尿液中出现固相(UO2)3(PO4)2·4H2O固相物质.
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  • [1] Anke M, Seeber O, Muller R, et al. Uranium transfer in the food chain from soil to plants, animals and man[J].Chemie der Erde, 2009, 69 (S2): 75-90
    [2] Parrish Randall R, Horstwood Matthew, Arnason John G,et al. Depleted uranium contamination by inhalation exposure and its detection after 20 years: Implications for human health assessment[J]. Science of the Total Environment, 2008, 390 (1): 58-68
    [3] Mirto H, Henge'-Napoli M H, Gibert R, et al. Intracellular behaviour of uranium(Ⅵ) on renal epithelial cell in culture (LLC-PK1): influence of uranium speciation[J].Toxicology Letters, 1999, 104 (3): 249-256
    [4] Montserrat F, Peter M M. Critical appraisal of available the modynamic data for the complexation of antimony (Ⅲ) and antimony (Ⅴ) by low molecular mass organic ligands[J]. J Environ Monit, 2005, 7 (12): 1226-1237
    [5] Guyton A C, Hall J E. Textbook of medical physiology, 10th ed[M]. Philadelphia: W B Saunders Company, 2000: 267
    [6] Iyengar G V, Kollmer W E, Bowen H J M.The elemental composition of human tissues and body fluids[M].New York: Verlag Chemic, 1978: 31-39
    [7] 蒋树斌,王和义,钟志京,等.热力学平衡模拟研究Am(Ⅲ)的人体毒性[J].环境化学,2008,27(2):138-141
    [8] Grenthe I, Fuger J, Konings R J M, et al. Chemical Thermodynamics of Uranium[M]. OECD Nuclear Energy Agency, Date Bank Issy-les-Moulineaux(France), 2003: 46-78
    [9] Scapolana S, Ansoborloa E, Moulinb C, et al. Investigations by time-resolved laser-induced fluorescence and capillary electrophoresis of the uranyl-phosphate species: application to blood serum[J].Journal of Alloys and Compounds, 1998,271: 106-111
    [10] Chevari S, Likhner D, Radiol Med. Uranyl-Peptide Interactions in Carbonate Solution with DAHK and Derivatives[J]. Inorganic chemistry, 1968, 13(8): 53-57
    [11] Kurttio P, Komulainen H, Leino A, et al. Bone as a possible target of chemical toxicity of natural uranium in drinking water[J].Environ Health Perspect, 2005, 113(1):68-72
    [12] Neuman W F, Fleming R W, Dounce A L, et al. The distribution and excretion of injected uranium[J].J Biol Chem, 1948,173: 737-748
    [13] Homma-Takeda S, Terada Y, Nakata A, et al. Elemental imaging of kidneys of adult rats exposed to uranium acetate[J]. Nuclear Instruments and Methods in Physics Research B, 2009: 2167-2170
    [14] Morrissey J J,Klahr S.Rapid communication.Enalaprilde creases nuclear factor kappa B activation in the kidney with ureteral obstruction[J].Kidney Int, 1997,52 (4):926-933
    [15] Katsuhiko A,Isao S,Kazumi I,et al.Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes[J].Kidney Int, 2002,62 (3):822-831
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  • 收稿日期:  2010-08-11
邓冰, 王和义, 蒋树斌, 马俊格. 铀在小鼠体内的分布及其影响因素的初步探讨[J]. 环境化学, 2011, 30(7): 1247-1252.
引用本文: 邓冰, 王和义, 蒋树斌, 马俊格. 铀在小鼠体内的分布及其影响因素的初步探讨[J]. 环境化学, 2011, 30(7): 1247-1252.
DENG Bing, WANG Heyi, JIANG Shubin, MA Junge. THE BIODISTRIBUTION OF URANIUM IN MICE[J]. Environmental Chemistry, 2011, 30(7): 1247-1252.
Citation: DENG Bing, WANG Heyi, JIANG Shubin, MA Junge. THE BIODISTRIBUTION OF URANIUM IN MICE[J]. Environmental Chemistry, 2011, 30(7): 1247-1252.

铀在小鼠体内的分布及其影响因素的初步探讨

  • 1. 中国工程物理研究院核物理与化学研究所, 绵阳, 621900
基金项目:

中国工程物理研究院科学技术发展基金资助项目(2009B0301029).

摘要: 通过尾静脉注射给药方式研究UO22+ 在小鼠体内的分布,通过建立包含主要体液的金属离子、小分子配体及UO22+及其配合物的热力学函数的热力学平衡模型,采用数值模拟方法研究UO22+在体液中的形态.研究表明,给药后铀的重要沉积部位为骨骼、肾脏和肝脾脏,主要通过小鼠肾脏排泄.肝脾脏器中铀的浓度随时间变化有两个峰值.血液中铀的清除速度较快.计算机模拟表明,血浆内UO22+主要以带电荷的UO22+配位离子形式存在,血浆内UO22+形态与总铀浓度相关.UO22+能与PO43-等离子形成溶度积很高的固态物质,造成UO22+长期沉积在骨骼,尿液中出现固相(UO2)3(PO4)2·4H2O固相物质.

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