Asian Journal of Ecotoxicology

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2020 Volume 15 Issue 4

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Tang Lan, Yu Jie, Xu Jie. The Effects of Environmental Endocrine Disruptors on Myocardial Mitochondrial: A Review[J]. Asian Journal of Ecotoxicology, 2020, 15(4): 123-128. doi: 10.7524/AJE.1673-5897.20190903002

Citation:

Tang Lan, Yu Jie, Xu Jie. The Effects of Environmental Endocrine Disruptors on Myocardial Mitochondrial: A Review[J]. Asian Journal of Ecotoxicology, 2020, 15(4): 123-128. doi: 10.7524/AJE.1673-5897.20190903002

The Effects of Environmental Endocrine Disruptors on Myocardial Mitochondrial: A Review

School of Public Health, Zunyi Medical University, Zunyi 563000, China

Corresponding author: Xu Jie, 649904039@qq.com
Received Date: 03/09/2019

Fund Project:

Abstract

The incidence of cardiac disease (e.g., coronary heart disease, myocarditis, myocardial infarction, etc.) continues to rise, and its etiology remains to be unknown. Mitochondrion is the energy producing organelle in the myocardial cell. The findings from the recent scientific literature show that exposure to environmental endocrine disruptors (EEDs) could induce myocardial mitochondrial dysfunction, which involved impaired respiratory chain, damaged mitochondrial membrane, decreased respiratory enzyme activity and antioxidant capacity, Ca²⁺ homeostasis disorder, increased oxidative stress, alterations in the expressions of regulatory genes which is related to mitochondrial energy metabolism, and mitochondrial fusion and division, etc. We reviewed the literature on the effects of EEDs (bisphenol A, nonylphenol, di (2-ethylhexyl) phthalate, aluminum phosphide, malathion, cadmium and mercury) and EEDs mixtures on myocardial mitochondria and its mechanism for the purpose of providing a potential target of cardiac disease treatment.
- environmental endocrine disruptors,
- cardiac toxicity,
- mitochondrial dysfunction,
- PGC-1α,
- oxidative stress

References

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The Effects of Environmental Endocrine Disruptors on Myocardial Mitochondrial: A Review

Corresponding author: Xu Jie, 649904039@qq.com

Received Date: 03/09/2019

Fund Project:

Key words:

Abstract: The incidence of cardiac disease (e.g., coronary heart disease, myocarditis, myocardial infarction, etc.) continues to rise, and its etiology remains to be unknown. Mitochondrion is the energy producing organelle in the myocardial cell. The findings from the recent scientific literature show that exposure to environmental endocrine disruptors (EEDs) could induce myocardial mitochondrial dysfunction, which involved impaired respiratory chain, damaged mitochondrial membrane, decreased respiratory enzyme activity and antioxidant capacity, Ca²⁺ homeostasis disorder, increased oxidative stress, alterations in the expressions of regulatory genes which is related to mitochondrial energy metabolism, and mitochondrial fusion and division, etc. We reviewed the literature on the effects of EEDs (bisphenol A, nonylphenol, di (2-ethylhexyl) phthalate, aluminum phosphide, malathion, cadmium and mercury) and EEDs mixtures on myocardial mitochondria and its mechanism for the purpose of providing a potential target of cardiac disease treatment.

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