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胡鹏, 张艳, 郭昌胜, 徐建. 水环境中滥用药物的环境学研究进展[J]. 环境化学, 2017, 36(8): 1711-1723. doi: 10.7524/j.issn.0254-6108.2017010301
引用本文: 胡鹏, 张艳, 郭昌胜, 徐建. 水环境中滥用药物的环境学研究进展[J]. 环境化学, 2017, 36(8): 1711-1723. doi: 10.7524/j.issn.0254-6108.2017010301
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HU Peng, ZHANG Yan, GUO Changsheng, XU Jian. Environmental studies on drugs of abuse in the aquatic environment[J]. Environmental Chemistry, 2017, 36(8): 1711-1723. doi: 10.7524/j.issn.0254-6108.2017010301
Citation: HU Peng, ZHANG Yan, GUO Changsheng, XU Jian. Environmental studies on drugs of abuse in the aquatic environment[J]. Environmental Chemistry, 2017, 36(8): 1711-1723. doi: 10.7524/j.issn.0254-6108.2017010301
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水环境中滥用药物的环境学研究进展

  • 1.

    中国环境科学研究院环境基准与风险评估国家重点实验室, 北京, 100012

  • 基金项目:

    国家自然科学基金（41673120），中央级公益性科研院所基本科研业务专项（2010YSKY-030）和北京市自然科学基金（8173058）资助.

Environmental studies on drugs of abuse in the aquatic environment

  • 1.

    State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China

  • Fund Project: Supported by the National Natural Science Foundation of China (41673120),Special Fund for Basic Scientific Research of Central Public Research Institutes (2010YSKY-030) and Beijing Natural Science Foundation (8173058).

  • 摘要: 滥用药物是一类非医用并被法律明令禁止使用的药物，近年来在世界各地的不同水环境中，包括污水、地表水、地下水甚至饮用水中均有检出，被视为一类新型污染物，逐渐成为环境领域的研究热点之一.本文在总结了国内外滥用药物相关环境学研究进展的基础上，对水环境中滥用药物的生态毒性、污染来源和途径、不同水体中的污染现状、环境行为及风险评估等进行了综述，总结了当前水环境中滥用药物分析检测方法和污水流行病学研究进展，并进一步分析了我国目前在滥用药物研究方面的现状，提出了该领域今后的研究方向和重点.
    Abstract: Drugs of abuse belong to the emerging contaminants that have drawn much attention of from both academic and regulatory communities. They have been widely detected in wastewater, surface water, groundwater and even in drinking water around the world, and have become a hot topic in environmental research. This paper reviewed the current state of knowledge on drugs of abuse, including their ecotoxicity, the sources and migration paths, the occurrence and concentration levels in different matrices, the environmenta fate, and environmental risk assessment. Meanwhile, the analytical methods and sewage epidemiology of drugs of abuse were also reviewed.The current research advance on drugs of abuse in China was summarized, and the field of research prospects were proposed as well in this paper.
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  • [1] DAUGHTON C G, TERNES T A. Pharmaceuticals and personal care products in the environment:Agents of subtle change[J]. Environmental Health Perspectives, 1999, 107(Suppl 6):907-938.
    [2] PEREIRA C D S, MARANHO L A, CORTEZ F S, et al. Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone[J]. Science of the Total Environment, 2016, 548:148-154.
    [3] KOLPIN D W, FURLONG E T, MEYER M T, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000:A national reconnaissance[J]. Environmental Science & Technology, 2002, 36(6):1202-1211.
    [4] NEBOT C, GIBB S W, BOYD K G. Quantification of human pharmaceuticals in water samples by high performance liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta, 2007, 598(1):87-94.
    [5] NARKOWICZ S, PŁOTKA J, POLKOWSKAŻ, et al. Prenatal exposure to substance of abuse:a worldwide problem[J]. Environment international, 2013, 54:141-163.
    [6] SLOAN M A. Illicit drug use/abuse and stroke[J]. Handbook of clinical neurology, 2008, 93:823-840.
    [7] MASTROIANNI N, BLEDA M J, LÓPEZ D A M, et al. Occurrence of drugs of abuse in surface water from four Spanish river basins:Spatial and temporal variations and environmental risk assessment[J]. Journal of Hazardous Materials, 2016, 316:134-142.
    [8] PAROLINI M, MAGNI S, CASTIGLIONI S, et al. Genotoxic effects induced by the exposure to an environmental mixture of illicit drugs to the zebra mussel[J]. Ecotoxicology & Environmental Safety, 2016, 132:26-30.
    [9] 张艳, 张婷婷, 郭昌胜,等. 北京市城市河流中精神活性物质的污染水平及环境风险[J]. 环境科学研究, 2016, 29(6):845-853.

    ZHANG Y, ZHANG T T, GUO C S, et al. Pollution status and environmental risks of illicit drugs in the urban rivers of Beijing[J]. Research of Environmental Sciences, 2016, 29(6):845-853(in Chinese).

    [10] HALL W D, DEGENHARDT L, SINDICICH N. Illicit drug use and the burden of disease-international encyclopedia of public health[J]. International Encyclopedia of Public Health, 2008, 3:523-530.
    [11] BURNS L. World Drug Report 2013 By United Nations Office on Drugs and Crime[J]. Drug and Alcohol Review, 2014, 33(2):216.
    [12] PAL R, MEGHARAJ M, KIRKBRIDE K P, et al. Illicit drugs and the environment-A review[J]. Science of the Total Environment, 2013, 463:1079-1092.
    [13] LIAO P H, HWANG C C, CHEN T H, et al. Developmental exposures to waterborne abused drugs alter physiological function and larval locomotion in early life stages of medaka fish[J]. Aquatic Toxicology, 2015, 165:84-92.
    [14] RADULOVIC N S, BLAGOJEVIC P D, STOJANOVIC-RADIC Z Z, et al. Antimicrobial plant metabolites:Structural diversity and mechanism of action[J]. Current Medicinal Chemistry, 2013, 20(7):932-952.
    [15] CHET I, HENIS Y, MITCHELL R. Effect of biogenic amines and cannabinoids on bacterial chemotaxis[J]. Journal of Bacteriology, 1973, 115(3):1215-1218.
    [16] CRIST R H, OBERHOLSER K, WONG B, et al. Amine-algae interactions:Cation-exchange and possible hydrogen bonding[J]. Environmental Science & Technology, 1992, 26(8):1523-1526.
    [17] ROSI-MARSHALL E J, SNOW D, BARTELT-HUNT S L, et al. A review of ecological effects and environmental fate of illicit drugs in aquatic ecosystems[J]. Journal of Hazardous Materials, 2015, 282:18-25.
    [18] BINELLI A, PEDRIALI A, RIVA C, et al. Illicit drugs as new environmental pollutants:Cyto-genotoxic effects of cocaine on the biological model Dreissena polymorpha[J]. Chemosphere, 2012, 86(9):906-911.
    [19] DARLAND T, DOWLING J E. Behavioral screening for cocaine sensitivity in mutagenized zebrafish[J]. Proceedings of the National Academy of Sciences, 2001, 98(20):11691-11696.
    [20] GAGNÉ F, BLAISE C, FOURNIER M, et al. Effects of selected pharmaceutical products on phagocytic activity in Elliptio complanata mussels[J]. Comparative Biochemistry and Physiology Part C:Toxicology & Pharmacology, 2006, 143(2):179-186.
    [21] LILIUS H, ISOMAA B, HOLMSTRÖM T. A comparison of the toxicity of 50 reference chemicals to freshly isolated rainbow trout hepatocytes and Daphnia magna[J]. Aquatic Toxicology, 1994, 30(1):47-60.
    [22] GAY F, MADDALONI M, VALIANTE S, et al. Endocrine disruption in the European eel, Anguilla anguilla, exposed to an environmental cocaine concentration[J]. Water, Air, & Soil Pollution, 2013, 224(5):1-11.
    [23] United Nations Office on Drugs and Crime. World drug report 2016[R]. New York:United Nations Office on Drugs and Crime, 2016.
    [24] 中国禁毒委员会. 2015年中国毒品形式报告[R]. 北京:中国禁毒委员会, 2016. Office of China National Narcotic Control Commission. Annual report 2015 on drug control in China[R]. Beijing:Office of China National Narcotic Control Commission, 2016(in Chinese).
    [25] MCCALL A K, BADE R, KINYUA J, et al. Critical review on the stability of illicit drugs in sewers and wastewater samples[J]. Water Research, 2016, 88:933-947.
    [26] RODAYAN A, MAJEWSKY M, YARGEAU V. Impact of approach used to determine removal levels of drugs of abuse during wastewater treatment[J]. Science of the Total Environment, 2014, 487:731-739.
    [27] BOLEDA M R, GALCERAN M T, VENTURA F. Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments[J]. Environmental Pollution, 2011, 159(6):1584-1591.
    [28] VAN NUIJS A L N, TARCOMNICU I, BERVOETS L, et al. Analysis of drugs of abuse in wastewater by hydrophilic interaction liquid chromatography-tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2009, 395(3):819-828.
    [29] VAZQUEZ-ROIG P, ANDREU V, BLASCO C, et al. SPE and LC-MS/MS determination of 14 illicit drugs in surface waters from the Natural Park of L'Albufera (València, Spain)[J]. Analytical and Bioanalytical Chemistry, 2010, 397(7):2851-2864.
    [30] GHEORGHE A, VAN NUIJS A, PECCEU B, et al. Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2008, 391(4):1309-1319.
    [31] MARI F, POLITI L, BIGGERI A, et al. Cocaine and heroin in waste water plants:A 1-year study in the city of Florence, Italy[J]. Forensic Science International, 2009, 189(1):88-92.
    [32] HUERTA-FONTELA M, GALCERAN M T, VENTURA F. Ultraperformance liquid chromatography-tandem mass spectrometry analysis of stimulatory drugs of abuse in wastewater and surface waters[J]. Analytical Chemistry, 2007, 79(10):3821-3829.
    [33] ZUCCATO E, CHIABRANDO C, CASTIGLIONI S, et al. Estimating community drug abuse by wastewater analysis[J]. Environmental Health Perspectives, 2008, 116(8):1027-1032.
    [34] GONZÁLEZ-MARIÑO I, QUINTANA J B, RODRÍGUEZ I, et al. Comparison of molecularly imprinted, mixed-mode and hydrophilic balance sorbents performance in the solid-phase extraction of amphetamine drugs from wastewater samples for liquid chromatography-tandem mass spectrometry determination[J]. Journal of Chromatography A, 2009, 1216(48):8435-8441.
    [35] POSTIGO C, LOPEZ DE ALDA M J, BARCELÓ D. Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry[J]. Analytical Chemistry, 2008, 80(9):3123-3134.
    [36] BIJLSMA L, SANCHO J V, PITARCH E, et al. Simultaneous ultra-high-pressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants, cocaine and its metabolites, and a cannabis metabolite in surface water and urban wastewater[J]. Journal of Chromatography A, 2009, 1216(15):3078-3089.
    [37] VAZQUEZ-ROIG P, ANDREU V, BLASCO C, et al. Spatial distribution of illicit drugs in surface waters of the natural park of Pego-Oliva Marsh (Valencia, Spain)[J]. Environmental Science and Pollution Research, 2012, 19(4):971-982.
    [38] BERSET J D, BRENNEISEN R, MATHIEU C. Analysis of llicit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-MS/MS)[J]. Chemosphere, 2010, 81(7):859-866.
    [39] MENDOZA A, RODRÍGUEZ-GIL J L, GONZÁLEZ-ALONSO S, et al. Drugs of abuse and benzodiazepines in the Madrid Region (Central Spain):Seasonal variation in river waters, occurrence in tap water and potential environmental and human risk[J]. Environment International, 2014, 70:76-87.
    [40] BOLEDA M R, HUERTA-FONTELA M, VENTURA F, et al. Evaluation of the presence of drugs of abuse in tap waters[J]. Chemosphere, 2011, 84(11):1601-1607.
    [41] GONZÁLEZ-MARIÑO I, QUINTANA J B, RODRÍGUEZ I, et al. Determination of drugs of abuse in water by solid-phase extraction, derivatisation and gas chromatography-ion trap-tandem mass spectrometry[J]. Journal of Chromatography A, 2010, 1217(11):1748-1760.
    [42] HERNÁNDEZ F, IBÁÑEZ M, BADE R, et al. Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry[J]. TrAC Trends in Analytical Chemistry, 2014, 63:140-157.
    [43] BARROSO M, GALLARDO E, VIEIRA D N, et al. Bioanalytical procedures and recent developments in the determination of opiates/opioids in human biological samples[J]. Analytical and Bioanalytical Chemistry, 2011, 400(6):1665-1690.
    [44] BASHEER C. Recent analytical strategies on "Date-Rape" drugs and its metabolites[J]. Journal of Applied Pharmaceutical Science, 2011, 1(6):21-28.
    [45] ATURKI Z, ROCCO A, FANALI S. Forensic drugs analysis:A review of miniaturized separation techniques[J]. Lc Gc Europe, 2015, 28(1):18-25.
    [46] CASTIGLIONI S, ZUCCATO E, CRISCI E, et al. Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry[J]. Analytical Chemistry, 2006, 78(24):8421-8429.
    [47] CASTIGLIONI S, ZUCCATO E, CHIABRANDO C, et al. Mass spectrometric analysis of illicit drugs in wastewater and surface water[J]. Mass Spectrometry Reviews, 2008, 27(4):378-394.
    [48] THORMANN W, MOLTENI S, CASLAVSKA J, et al. Clinical and forensic applications of capillary electrophoresis[J]. Electrophoresis, 1994, 15(1):3-12.
    [49] ANASTOS N, BARNETT N W, LEWIS S W. Capillary electrophoresis for forensic drug analysis:A review[J]. Talanta, 2005, 67(2):269-279.
    [50] TAGLIARO F, PASCALI J P, LEWIS S W. Capillary electrophoresis in forensic chemistry[J]. Encyclopedia of Forensic Sciences, 2013:567-572.
    [51] BACIU T, BOTELLO I, BORRULL F, et al. Capillary electrophoresis and related techniques in the determination of drugs of abuse and their metabolites[J]. TrAC Trends in Analytical Chemistry, 2015, 74:89-108.
    [52] CHIAIA A C, BANTA-GREEN C, FIELD J. Eliminating solid phase extraction with large-volume injection LC/MS/MS:Analysis of illicit and legal drugs and human urine indicators in US wastewaters[J]. Environmental Science & Technology, 2008, 42(23):8841-8848.
    [53] METCALFE C, TINDALE K, LI H, et al. Illicit drugs in Canadian municipal wastewater and estimates of community drug use[J]. Environmental Pollution, 2010, 158(10):3179-3185.
    [54] HUERTA-FONTELA M, GALCERAN M T, MARTIN-ALONSO J, et al. Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain[J]. Science of the Total Environment, 2008, 397(1/3):31-40.
    [55] KASPRZYK-HORDERN B, DINSDALE R M, GUWY A J. Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2008, 391(4):1293-1308.
    [56] DU P, LI K, LI J, et al. Methamphetamine and ketamine use in major Chinese cities, a nationwide reconnaissance through sewage-based epidemiology[J]. Water Research, 2015, 84:76-84.
    [57] BOLES T H, WELLS M J M. Analysis of amphetamine and methamphetamine as emerging pollutants in wastewater and wastewater-impacted streams[J]. Journal of Chromatography A, 2010, 1217(16):2561-2568.
    [58] KASPRZYK-HORDERN B, DINSDALE R M, GUWY A J. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters[J]. Water Research, 2009, 43(2):363-380.
    [59] MACKUL'AK T, BIROŠOVÁ L, BODÍK I, et al. Zerovalent iron and iron (VI):Effective means for the removal of psychoactive pharmaceuticals and illicit drugs from wastewaters[J]. Science of the Total Environment, 2016, 539:420-426.
    [60] ABDELMELEK S B, GREAVES J, ISHIDA K P, et al. Removal of pharmaceutical and personal care products from reverse osmosis retentate using advanced oxidation processes[J]. Environmental Science & Technology, 2011, 45(8):3665-3671.
    [61] MACKUL'AK T, MOSNÝ M, GRABIC R, et al. Fenton-like reaction:A possible way to efficiently remove illicit drugs and pharmaceuticals from wastewater[J]. Environmental Toxicology and Pharmacology, 2015, 39(2):483-488.
    [62] NEFAU T, KAROLAK S, CASTILLO L, et al. Presence of illicit drugs and metabolites in influents and effluents of 25 sewage water treatment plants and map of drug consumption in France[J]. Science of the Total Environment, 2013, 461:712-722.
    [63] ANDRÉS-COSTA M J, RUBIO-LÓPEZ N, SUÁREZ-VARELA M M, et al. Occurrence and removal of drugs of abuse in Wastewater Treatment Plants of Valencia (Spain)[J]. Environmental Pollution, 2014, 194:152-162.
    [64] SUBEDI B, KANNAN K. Mass loading and removal of select illicit drugs in two wastewater treatment plants in New York State and estimation of illicit drug usage in communities through wastewater analysis[J]. Environmental Science & Technology, 2014, 48(12):6661-6670.
    [65] BOLEDA M R, GALCERAN M T, VENTURA F. Monitoring of opiates, cannabinoids and their metabolites in wastewater, surface water and finished water in Catalonia, Spain[J]. Water Research, 2009, 43(4):1126-1136.
    [66] ZUCCATO E, CASTIGLIONI S, BAGNATI R, et al. Illicit drugs, a novel group of environmental contaminants[J]. Water Research, 2008, 42(4):961-968.
    [67] JURADO A, MASTROIANNI N, VÀZQUEZ-SUÑÉ E, et al. Drugs of abuse in urban groundwater. A case study:Barcelona[J]. Science of the Total Environment, 2012, 424:280-288.
    [68] LI K, DU P, XU Z, et al. Occurrence of illicit drugs in surface waters in China[J]. Environmental Pollution, 2016, 213:395-402.
    [69] YAO B, LIAN L, PANG W, et al. Determination of illicit drugs in aqueous environmental samples by online solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry[J]. Chemosphere, 2016, 160:208-215.
    [70] BARTELT-HUNT S L, SNOW D D, DAMON T, et al. The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska[J]. Environmental Pollution, 2009, 157(3):786-791.
    [71] BAKER D R, KASPRZYK-HORDERN B. Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment:New developments[J]. Science of the Total Environment, 2013, 454:442-456.
    [72] MENDOZA A, DE ALDA M L, GONZÁLEZ-ALONSO S, et al. Occurrence of drugs of abuse and benzodiazepines in river waters from the Madrid Region (Central Spain)[J]. Chemosphere, 2014, 95:247-255.
    [73] BONES J, THOMAS K V, PAULL B. Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals[J]. Journal of Environmental Monitoring, 2007, 9(7):701-707.
    [74] LIN A Y C, LIN Y C, LEE W N. Prevalence and sunlight photolysis of controlled and chemotherapeutic drugs in aqueous environments[J]. Environmental Pollution, 2014, 187:170-181.
    [75] LIN A Y C, WANG X H, LIN C F. Impact of wastewaters and hospital effluents on the occurrence of controlled substances in surface waters[J]. Chemosphere, 2010, 81(5):562-570.
    [76] KUO C S, LIN C F, HONG P K A. Photocatalytic mineralization of codeine by UV-A/TiO2-kinetics, intermediates, and pathways[J]. Journal of Hazardous Materials, 2016, 301:137-144.
    [77] KUO C S, LIN C F, HONG P K A. Photocatalytic degradation of methamphetamine by UV/TiO2 -kinetics, intermediates, and products[J]. Water Research, 2015, 74:1-9.
    [78] PLÓSZ B G, REID M J, BORUP M, et al. Biotransformation kinetics and sorption of cocaine and its metabolites and the factors influencing their estimation in wastewater[J]. Water Research, 2013, 47(7):2129-2140.
    [79] STEIN K, RAMIL M, FINK G, et al. Analysis and sorption of psychoactive drugs onto sediment[J]. Environmental Science & Technology, 2008, 42(17):6415-6423.
    [80] PALÓR, MEGHARAJ M, KIRKBRIDE K P, et al. Biotic and abiotic degradation of illicit drugs, their precursor, and by-products in soil[J]. Chemosphere, 2011, 85(6):1002-1009.
    [81] VALCÁRCEL Y, MARTÍNEZ F, GONZÁLEZ-ALONSO S, et al. Drugs of abuse in surface and tap waters of the Tagus River basin:heterogeneous photo-Fenton process is effective in their degradation[J]. Environment International, 2012, 41:35-43.
    [82] THOMAS K V, BIJLSMA L, CASTIGLIONI S, et al. Comparing illicit drug use in 19 European cities through sewage analysis[J]. Science of the Total Environment, 2012, 432:432-439.
    [83] POCURULL E. Illicit Drugs in the Environment:Occurrence, analysis, and fate using mass spectrometry[M]. New York:Wiley, 2012.
    [84] HERNANDO M D, MEZCUA M, FERNÁNDEZ-ALBA A R, et al. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments[J]. Talanta, 2006, 69(2):334-342.
    [85] SANDERSON H, JOHNSON D J, REITSMA T, et al. Ranking and prioritization of environmental risks of pharmaceuticals in surface waters[J]. Regulatory Toxicology and Pharmacology, 2004, 39(2):158-183.
    [86] DAUGHTON C G. Pharmaceuticals and personal care products in the environment:Scientific and regulatory issues[M]. Washington:American Chemical Society, 2001:348-364.
    [87] ZUCCATO E, CHIABRANDO C, CASTIGLIONI S, et al. Cocaine in surface waters:A new evidence-based tool to monitor community drug abuse[J]. Environmental Health, 2005, 4(1):1-7.
    [88] CASTIGLIONI S, ZUCCATO E. Illicit drugs as emerging contaminants[M]. Washington:American Chemical Society,2010:119-136.
    [89] VAN NUIJS A L N, PECCEU B, THEUNIS L, et al. Can cocaine use be evaluated through analysis of wastewater? A nation-wide approach conducted in Belgium[J]. Addiction, 2009, 104(5):734-741.
    [90] POSTIGO C, DE ALDA M J L, BARCELÓ D. Drugs of abuse and their metabolites in the Ebro River basin:Occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation[J]. Environment International, 2010, 36(1):75-84.
    [91] WANG D G, ZHENG Q D, WANG X P, et al. Illicit drugs and their metabolites in 36 rivers that drain into the Bohai Sea and north Yellow Sea, north China[J]. Environmental Science and Pollution Research, 2016:1-9.
    [92] MALDANER A O, SCHMIDT L L, LOCATELLI M A F, et al. Estimating cocaine consumption in the Brazilian Federal District (FD) by sewage analysis[J]. Journal of the Brazilian Chemical Society, 2012, 23(5):861-867.
    [93] VUORI E, HAPPONEN M, GERGOV M, et al. Wastewater analysis reveals regional variability in exposure to abused drugs and opioids in Finland[J]. Science of the Total Environment, 2014, 487:688-695.
    [94] THAI P K, LAI F Y, EDIRISINGHE M, et al. Monitoring temporal changes in use of two cathinones in a large urban catchment in Queensland, Australia[J]. Science of the Total Environment, 2016, 545:250-255.
    [95] TERZIC S, SENTA I, AHEL M. Illicit drugs in wastewater of the city of Zagreb (Croatia)-estimation of drug abuse in a transition country[J]. Environmental Pollution, 2010, 158(8):2686-2693.
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  • 收稿日期:  2017-01-03
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水环境中滥用药物的环境学研究进展

  • 1. 中国环境科学研究院环境基准与风险评估国家重点实验室, 北京, 100012
  • 收稿日期:  2017-01-03
基金项目:

国家自然科学基金（41673120），中央级公益性科研院所基本科研业务专项（2010YSKY-030）和北京市自然科学基金（8173058）资助.

摘要: 滥用药物是一类非医用并被法律明令禁止使用的药物，近年来在世界各地的不同水环境中，包括污水、地表水、地下水甚至饮用水中均有检出，被视为一类新型污染物，逐渐成为环境领域的研究热点之一.本文在总结了国内外滥用药物相关环境学研究进展的基础上，对水环境中滥用药物的生态毒性、污染来源和途径、不同水体中的污染现状、环境行为及风险评估等进行了综述，总结了当前水环境中滥用药物分析检测方法和污水流行病学研究进展，并进一步分析了我国目前在滥用药物研究方面的现状，提出了该领域今后的研究方向和重点.

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