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In Vitro法评估铅污染土壤对人体的生物有效性

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唐翔宇, 朱永官, 陈世宝. In Vitro法评估铅污染土壤对人体的生物有效性[J]. 环境化学, 2003, 22(5): 503-506.
引用本文: 唐翔宇, 朱永官, 陈世宝. In Vitro法评估铅污染土壤对人体的生物有效性[J]. 环境化学, 2003, 22(5): 503-506.
shu
TANG Xiang-yu, ZHU Yong-guan, CHEN Shi-bao. ASSESSMENT OF LEAD BIOACCESSIBILITY IN CONTAMINATED SOIL USING IN VITRO TEST[J]. Environmental Chemistry, 2003, 22(5): 503-506.
Citation: TANG Xiang-yu, ZHU Yong-guan, CHEN Shi-bao. ASSESSMENT OF LEAD BIOACCESSIBILITY IN CONTAMINATED SOIL USING IN VITRO TEST[J]. Environmental Chemistry, 2003, 22(5): 503-506.
shu

In Vitro法评估铅污染土壤对人体的生物有效性

  • 1.

    中国科学院生态环境研究中心, 北京, 100085;

  • 2.

    中国农业科学院土壤肥料研究所, 北京, 100081

  • 基金项目:

    国家自然科学基金项目(40235054)

    中国科学院知识创新工程重大方向性项目(KZCX3SW424)资助.

ASSESSMENT OF LEAD BIOACCESSIBILITY IN CONTAMINATED SOIL USING IN VITRO TEST

  • 1.

    Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences, Beijing, 100085;

  • 2.

    Institute of Soil Science and Fertilizer, the Chinese of Aricultmal Sciences, Beijing, 100081

  • Fund Project:

  • 摘要: 采用基于生理学的InVitro实验, 测定经口无意摄入的铅污染土壤在人体内的生物有效性.通过模拟人体的胃和小肠环境, 研究土壤中铅被消化道吸收的最大量.结果表明, 在铅污染土壤中施加羟基磷灰石后, 铅对人体的生物有效性下降约20倍.
    Abstract: Physiologically based In Vitro test was used to estimate Pb bioaccessibility of inadvertently ingested soil in human.The maximum Pb absorption by human was assessed in an artificial system of human gastro-intestinal environment.Results showed that the addition of hydroxyapatite to Pb contaminated soil could significantly reduce the Pb oral bioaccessibility in human by a factor of 20.
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  • [1] Ruby M V,Schoof R.,Brattin W et al.,Advances in Evaluating the Oral Bioavailability of Inorganics in Soil for Use in Human Health Risk Assessment.Environmental Science and Technology,1999,33(21)∶3697-3705
    [2] Ruby M V,Davis A,Schoof R et al.,Estimation of Lead and Arsenic Bioavaibility Using a Physiologically Based Extraction Test.Environmental Science and Technology,1996,30(2)∶422-430
    [3] Rodriguez R R,Basta N T,Casteel S W et al.,An In Vitro Gastrointestinal Method to Estimate Bioavailable Arsenic in Contaminated Soils and Solid Media.Environmental Science and Technology,1999,33(4)∶642
    [4] Ma Q Y,Traina S J,Logan T J,In Situ Lead Immobilization by Apatite.Environmental Science and Technology,1993,27∶1803-1810
    [5] Davis S,Waller P,Quantiative Estimates of Soil Ingestion in Normal Children Between the Ages of 2 and 7 Years;Population-Based Estimates Using Aluminium,Silicon,and Titanium As Soil Tracer Elements.Arch Environ Health,1990,45∶112-122
    [6] Van Wijnen J H,Clausing P,Brunekreef B,Estimated Soil Ingestion by Children.Environ.Res.,1990,51∶147-162
    [7] Calabrese E J,Stanek E J,James R C et al.,Soil Ingestion.A Concern for Acute Toxicity in Children.J Environ Health,1999,61∶18-23
    [8] Healy M A,Harrison P G,Aslam M et al.,Lead Sulphide and Traditional Preparations;Routes for Ingestion,Solubility and Reactions in Gastric fluid.Journal of Clinical Hospital Pharmacy,1982,7∶169-173
    [9] Xintaras C,Analysis Paper;Impact of Lead Contaminated Soil on Public Health.US Department of Health and Human Services Agency for Toxic Substances and Disease Registry,1992,Atlanta Georgia 30333 USA
    [10] USEPA,Guidance Manual for the Integrated Exposure Uptake Biokinetic Model for Lead in Children(IEUBK).Prepared by the Technical Review Workgroup for Lead for the Office of Emergency an Remedial Response,USEPA.Publication Number 9285.7-15-1 EPA 540-R-93-081 PB93-963510,with Document Production Assistance from Envir.Criteria and Assessment Office,USEPA,1994,Research Triangle Park,NC 27711
    [11] Oomen A G,Tolls J,Sips A J A M et al.,In Vitro Intestinal Lead Uptake and Transport in Relation to Speciation.Archives of Environmental Contamination and Toxicology,2003,44∶116-124
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唐翔宇, 朱永官, 陈世宝. In Vitro法评估铅污染土壤对人体的生物有效性[J]. 环境化学, 2003, 22(5): 503-506.
引用本文: 唐翔宇, 朱永官, 陈世宝. In Vitro法评估铅污染土壤对人体的生物有效性[J]. 环境化学, 2003, 22(5): 503-506.
shu
TANG Xiang-yu, ZHU Yong-guan, CHEN Shi-bao. ASSESSMENT OF LEAD BIOACCESSIBILITY IN CONTAMINATED SOIL USING IN VITRO TEST[J]. Environmental Chemistry, 2003, 22(5): 503-506.
Citation: TANG Xiang-yu, ZHU Yong-guan, CHEN Shi-bao. ASSESSMENT OF LEAD BIOACCESSIBILITY IN CONTAMINATED SOIL USING IN VITRO TEST[J]. Environmental Chemistry, 2003, 22(5): 503-506.
shu

In Vitro法评估铅污染土壤对人体的生物有效性

  • 1.  中国科学院生态环境研究中心, 北京, 100085;
  • 2.  中国农业科学院土壤肥料研究所, 北京, 100081
基金项目:

国家自然科学基金项目(40235054)

中国科学院知识创新工程重大方向性项目(KZCX3SW424)资助.

摘要: 采用基于生理学的InVitro实验, 测定经口无意摄入的铅污染土壤在人体内的生物有效性.通过模拟人体的胃和小肠环境, 研究土壤中铅被消化道吸收的最大量.结果表明, 在铅污染土壤中施加羟基磷灰石后, 铅对人体的生物有效性下降约20倍.

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