水力空化(HC)联合高级氧化技术去除典型手性药物的研究进展
Degradation of chiral drugs by hydrodynamic cavitation (HC) combined with advanced oxidation technology
-
摘要: 普通药物中大部分是具有一对对映异构体手性结构的手性药物（CDs），且CDs作为一种新型微污染物在水体中被频繁发现.该药物因其种类和组成的不同，内部的对映异构体可能会表现出特异性，如体现在毒性、与蛋白质结合吸收以及在河流中自然衰减率等方面.而高级氧化法（AOPs），如空化（水力空化和声空化）、Fenton法和光催化法等技术手段，在去除CDs方面已表现出较大潜力.本研究基于对映体结构，全面梳理了CDs的性质、来源及对人类健康的影响，拟探究水环境中典型CDs的手性反转和药理学立体选择性特征，并归纳了水力空化方法联合AOP技术对萘普生、布洛芬等典型CDs去除效果特点，重点讨论了该方法作用机理与其利弊，探究最优适用条件，最终归纳出目前CDs分离分析技术的瓶颈及未来环境中CDs去除技术的研究趋势.Abstract: Chiral drugs (CDs)as a type of emerging micropollutantswere frequently found in rivers and drinking water. According to statistics, most of the common drugs have a chiral structure with a pair of enantiomers inside. For CDs, internal enantiomers usually exhibit different properties due to their different species and compositions, which are reflected in toxicity, combined absorption with proteins, and natural decay rate in rivers. In addition, advanced oxidation methods including cavitation(hydrodynamic cavitation and acoustic cavitation), Fenton and photocatalysis have shown great promising in the removal of CDs. Based on enantiomers,the nature, source and impact of chiral drugs on human health were comprehensively analyzed. It was proposed to investigate the chiral reversal and pharmacological stereoselectivity of typical chiral drugs in water. And then the removal rate of chiral drugs such as carbamazepine and ibuprofen by hydrodynamic cavitation combined with other advanced oxidation methods were summarized.Three advanced oxidation methods, which were applied in combination with hydrodynamic cavitation, were also discussed. Its mechanism, advantages and disadvantages were analyzed in order to get the optimal conditions. Consequently, the bottleneck of the separation and analysis methods of chiral drugs and the prospects for the removal of chiral drugs in environments were proposed.
-
-
[1] GARRISON A W. Probing the enantioselectivity of chiral pesticides[J].Environ Sci Technol,2006,40:16-23. [2] KOLPIND, FURLONG E, MEYER M, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. Streams//Water Encyclopedia[M]. John Wiley & Sons, Inc, 2005. [3] STANLEY J K,RAMIREZ A J,CHAMBLISS C K,et al. Enantiospecific sublethal effects of the antidepressant fluoxetine to a model aquatic vertebrate and invertebrate[J].Chemosphere,2007,69(1):9-16. [4] RENNER R. Chiral compounds show promise as environmental tracers[J]. Environ Sci Technol,1996,30:16A-17A. [5] JELICA, GROS M, GINEBREDA A, et al. Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment[J]. Water Research,2011, 45(3):1165-1176. [6] ANDREOZZIR, RAFFAELE M, PAXEUS N. Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment[J]. Chemosphere, 2003, 50(10):1319-1330. [7] VILLEGAS G P, SILVA A J, GIRALDO A L, et al. Enhancement and inhibition effects of water matrices during the sonochemical degradation of the antibiotic dicloxacillin[J]. Ultrasonics Sonochemistry, 2015, 22:211-219. [8] SANGANYADOE, LU Z, FU Q, et al. Chiral pharmaceuticals:A review on their environmental occurrence and fate processes[J]. Water Research, 2017, 124:527-542. [9] DAVID M, RONALD G, KAI T.Mechanisms of acetohydroxyacid synthases[J].Current Opinion in Chemical Biology, 2005, 9:475-481. [10] RIVERA U, JOSE, GOMEZ P, et al. Tetracycline removal from water by adsorption/bioadsorption on activated carbons and sludge-derived adsorbents[J]. Journal of Environmental Management, 2013, 131(Complete):16-24. [11] AHMED M B, ZHOU J L, NGO H H, et al. Progress in the biological and chemical treatment technologies for emerging contaminant removal from wastewater:A critical review[J]. Journal of Hazardous Materials, 2016,323(Pt A):274-298. [12] CRUZ M, CARLES, FERRANDO C L, et al. Degradation of pharmaceuticals in non-sterile urban wastewater by Trametes versicolor in a fluidized bed bioreactor[J]. Water Research, 2013, 47(14):5200-5210. [13] DAWAS M A, GUR R S, LERMAN S, et al. Co-metabolic oxidation of pharmaceutical compounds by a nitrifying bacterial enrichment[J]. Bioresource Technology, 2014, 167:336-342. [14] COMBARROS R G, ROSAS I, LAVIN, A. G, et al. Influence of biofilm on activated carbon on the adsorption and biodegradation of salicylic acid in wastewater[J]. Water, Air, & Soil Pollution, 2014, 225(2):1858-245. [15] REIS PATRICIA J M, REIS A C, RICKEN B, et al. Biodegradation of sulfamethoxazole and other sulfonamides by Achromobacter denitrificans PR1[J]. Journal of Hazardous Materials, 2014, 280:741-749. [16] CARLOS E, RODRIGUEZ R, ENRIQUEB, et al. Removal of pharmaceuticals, polybrominated flame retardants and UV-filters from sludge by the fungus Trametes versicolor in bioslurry reactor[J]. Journal of Hazardous Materials, 2012, 233-234:235-243. [17] GROSM, CRUZ M C, MARCO U E, et al. Biodegradation of the X-ray contrast agent iopromide and the fluoroquinolone antibiotic ofloxacin by the white rot fungus Trametes versicolor in hospital wastewaters and identification of degradation products[J]. Water Research, 2014, 60:228-241. [18] MARCO U E, MIRIAM PT, PAQUI B, et al. Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR[J]. Bioresource Technology, 2010, 101(7):2159-2166. [19] MARCO U E, AEANDA E, CAMINAL G, et al. Induction of hydroxyl radical production in Trametes versicolor to degrade recalcitrant chlorinated hydrocarbons[J]. Bioresource Technology, 2009, 100(23):5757-5762. [20] FONO L J, SEDLAK D L. Use of the chiral pharmaceutical propranolol to identify sewage discharges into surface waters[J]. Environmental Science & Technology, 2005, 39(23):9244-9252. [21] LUOY, GUO W, NGO H H, et al. A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment[J]. Science of the Total Environment, 2014, 473-474:619-641. [22] TIXIER, CELINE, SINGER H P, et al. Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters[J]. Environmental Science & Technology, 2003, 37(6):1061-1068. [23] SUZUKI T, KOSUGI Y, HOSAKA M, et al. Occurrence and behavior of the chiral anti-inflammatory drug naproxen in an aquatic environment[J]. Environmental Toxicology & Chemistry, 2015, 33(12):2671-2678. [24] SUGAWARAY, FUJIHARA M, MIURA Y, et al. Studies on the fate of naproxen.Ⅱ. Metabolic fate in various animals and man[J]. Chemical & Pharmaceutical Bulletin, 1978, 26(11):3312-3321. [25] PACKER J L, WERNER J J, LATCH D E, et al. Photochemical fate of pharmaceuticals in the environment:Naproxen, diclofenac, clofibric acid, and ibuprofen[J]. Aquatic Sciences-Research Across Boundaries, 2003, 65(4):342-351. [26] FONE L J, SEDLAK D L. Use of the chiral pharmaceutical propranolol to identify sewage discharges into surface waters[J]. Environmental Science & Technology, 2005, 39(23):9244-9252. [27] ROBERTL.Comments on "Chiral pharmaceuticals:Environment sources, potential human health impacts,remediation technologies and future perspective"[J]. Environment International,2019,122:412-415. [28] 刘瑞霞, 李佳熹, 刘晓玲. 环境介质中手性药物对映体分离分析及环境行为研究进展[J]. 环境工程学报, 2017,11(6):3341-3352. LIU R X,LI J X,LIU X L. Research progress on separation, analysis and environmental behavior ofchiral pharmaceutical enantiomers in environmental matrix[J]. Chinese Journal of Environmental Engineering, 2017,11(6):3341-3352(in Chinese).
[29] LI P, SONE Y, YU S,et al. The effect of hydrodynamic cavitation on Microcystis aeruginosa:Physicaland chemical factors[J]. Chemosphere, 2015, 136:245-251. [30] FRANC J P, MICHEL J M. Fundamentals of cavitation[J]. Fluid Mechanics & Its Applications, 2004, 76(11):1-46. [31] LI P, SONG Y, YU S. Removal of microcystis aeruginosa using hydrodynamic cavitation:Performance and mechanisms[J]. Water Research, 2014, 62(Complete):241-248. [32] CRAVOTTOG, CINTAS P. Power ultrasound in organic synthesis:Moving cavitational chemistry from academia to innovative and large-scale applications[J]. Chemical Society Reviews, 2006, 35(2):180-196. [33] TAOY, CAI J, HUAI X, et al. Application of hydrodynamic cavitation to wastewater treatment[J]. Chemical Engineering & Technology, 2016, 39(8):1363-1376. [34] TAOY, CAI J, HUAI X, et al. A novel antibiotic wastewater degradation technique combining cavitating jets impingement with multiple synergetic methods[J]. Ultrasonics Sonochemistry, 2018, 44:36-44. [35] GOGATE P R.Cavitational reactors for process intensification of chemical processing applications:A critical review[J]. Chemical Engineering and Processing, 2008, 47(4):515-527. [36] CINTAS P, LUCHE J L. Green chemistry. The sonochemical approach[J]. Green Chemistry, 1999, 1(3):115-125. [37] CAI M Q, GUAN Y X, YAO S J, et al. Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) for micronization of levofloxacin hydrochloride[J]. The Journal of Supercritical Fluids, 2008, 43(3):524-534. [38] HUTT A J, CALDWELL J. The metabolic chiral inversion of 2-arylpropanoic acids:A novel route with pharmacological consequences[J]. Pharm Pharmacol, 1983,35:693-704. [39] THANEKAR P, GARG S, GOGATE P R.Hybrid treatment strategies based on hydrodynamic cavitation, advanced oxidation processes, and aerobic oxidation for efficient removal of naproxen[J]. Industrial & Engineering Chemistry Research,2019,59:4058-4070. [40] GOGATE P R. Cavitation:An auxiliary technique in wastewater treatment schemes[J]. Advances in Environmental Research, 2002(3):335-358. [41] MATEVZ D,TJASA G B,ION G, et al.Use of hydrodynamic cavitation in (waste)water treatment[J]. Ultrasonics Sonochemistry,2016,29:577-588. [42] MARINELLA F, ASPERGERD, KANTIANI L, et al. Assessment of the acute toxicity of triclosan and methyl triclosan in wastewater based on the bioluminescence inhibition of vibriofischeri[J]. Analytical & Bioanalytical Chemistry, 2008, 390(8):1999-2007. [43] ZUPANC M, KOSJEK T, PETKOVEK M, et al. Shear-induced hydrodynamic cavitation as a tool for pharmaceutical micropollutants removal from urban wastewater[J]. Ultrasonics Sonochemistry, 2014, 21(3):1213-1221. [44] MUSMARRA D,PRISCIANDARO M, CAPOCELLI M, et al. Degradation of ibuprofen by hydrodynamic cavitation:Reaction pathways and effect of operational parameters[J]. Ultrasonics Sonochemistry, 2016, 29:76-83. [45] WANG Z, SRIVASTAVA V, AMBAT I,et al. Degradation of Ibuprofen by UV-LED/catalytic advanced oxidation process[J]. Journal of Water Process Engineering, 2019, 31:1-9. [46] ARANAMI K, READMAN J W. Photolytic Degradation of triclosan in freshwater and seawater[J]. Chemosphere,2007, 66:1052-1056. [47] BAGAL M V, GOGATE P R. Degradation of diclofenac sodium using combined processes based on hydrodynamic cavitation and heterogeneous photocatalysis[J]. Ultrasonics Sonochemistry, 2014, 21(3):1035-1043. [48] OLLER S, MALATO J A, SANCHEZ P, et al.Combination of advanced oxidation processes and biologicaltreatments for wastewater decontamination:A review[J]. Science of the Total Environment, 2011,409(20):4141-4166. -
点击查看大图
计量
- 文章访问数: 2799
- HTML全文浏览数: 2799
- PDF下载数: 128
- 施引文献: 0
下载:
