摘要:
镉极易在人体内蓄积且自然排泄缓慢,对人体健康危害严重,因此关于镉毒性的干预措施及机理研究意义重大。系统总结了螯合剂、金属硫蛋白、营养元素(锌、硒、钙、铁和维生素等),以及中药对镉毒性的干预作用及其机理。目前,镉中毒的许多干预措施均是利用与镉具有更高亲和性的一些外加物质,在动物体内与镉形成易于排出体外的复合物,再通过动物正常的生理活动将镉排出,以消除镉对机体内一些必需元素的正常新陈代谢活动的干扰。中药对镉中毒的干预机理可能成为新的研究热点。
Abstract:
Cadmium (Cd) is easily accumulated in humans but difficult to be discharged by organism itself. Since the accumulated Cd causes serious effects on human health, it is very important to investigate the methods and mechanisms of inhibiting Cd toxicity. In this paper, inhibiting Cd toxicity by chelator, metallothionein, nutrient elements (zinc, selenium, calcium, iron and vitamins), and Chinese traditional medicine was summarized. The corresponding inhibition mechanisms were discussed and reviewed. Until now, many measurements for inhibiting Cd toxicity all utilize some additive substances with higher affinity to Cd so as to form some easily-discharged complexes which can be removed out of animal body through its normal physiological activities. Therefore, the interference of Cd with normal metabolic activities of necessary elements was eliminated. The mechanisms of inhibiting Cd toxicity by Chinese traditional medicine might be a promising research area.
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