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邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展

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罗艺文, 高盼, 闫路, 张效伟, 于红霞, 史薇, 于南洋. 邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展[J]. 环境化学, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
引用本文: 罗艺文, 高盼, 闫路, 张效伟, 于红霞, 史薇, 于南洋. 邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展[J]. 环境化学, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
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LUO Yiwen, GAO Pan, YAN Lu, ZHANG Xiaowei, YU Hongxia, SHI Wei, YU Nanyang. Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes[J]. Environmental Chemistry, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
Citation: LUO Yiwen, GAO Pan, YAN Lu, ZHANG Xiaowei, YU Hongxia, SHI Wei, YU Nanyang. Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes[J]. Environmental Chemistry, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
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邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展

  • 污染控制与资源化研究国家重点实验室, 南京大学环境学院, 南京, 210023

    • 通讯作者: 于南洋, E-mail: yuny@nju.edu.cn
  • 基金项目:

    国家重点研发计划（2018YFC1801604），国家自然科学基金（21922603），江苏省优秀青年科学基金（BK20170077），中央高校基本科研业务费专项资金（021114380139）和国家水污染控制与处理科技重大项目（2017ZX07202-001，2017ZX07602-002）资助.

Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes

  • State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China

    • Corresponding author: YU Nanyang, yuny@nju.edu.cn
  • Fund Project: Supported by the National Key R&D Program of China (2018YFC1801604), the Natural Science Foundation of China (21922603), the Science Fund for Excellent Young Scholars of Jiangsu Province (BK20170077), the Fundamental Research Funds for the Central Universities (021114380139) and the National Water Pollution Control and Treatment Science and Technology Major Project (2017ZX07202-001, 2017ZX07602-002).

  • 摘要: 邻苯二甲酸二丁酯（di-n-butyl phthalate，DnBP）和邻苯二甲酸二异丁酯（diisobutyl phthalate，DiBP）是广泛用于塑料、树脂和橡胶制品中的邻苯二甲酸酯类增塑剂，曾在各种环境介质中频繁检出.现有研究表明，DnBP和DiBP对人类和其他动物具有显著的内分泌干扰效应以及生殖发育毒性等不良影响，因而在许多国家和地区被限制使用，由此市面上涌现出了一些替代品增塑剂.本文结合国内外关于DnBP和DiBP及其替代品的研究成果，综述了DnBP和DiBP在个体、细胞和分子水平上的内分泌干扰效应与机制以及在市场应用中的替代情况，并且选取了4种典型的替代品（邻苯二甲酸二异壬酯、环己烷-1，2-二羧酸二异壬酯、二苯甲酸二聚丙二醇酯、三乙酸甘油酯）对其内分泌干扰效应进行对比分析.研究结果表明，DnBP和DiBP在环境低浓度下能够影响类固醇激素合成通路中关键基因的表达，进而改变生物体内类固醇激素的水平，高浓度暴露时则会对生殖器官造成损伤并最终降低生殖能力，妊娠期暴露还会对后代产生相同的影响.DnBP和DiBP的4种替代品在急性毒性、持久性和生物可累积性方面均有所降低，内分泌干扰效应也显著降低，但缺乏系统的研究以全面评估其可替代性.提出今后替代品的安全性评估应纳入更多的毒性终点并深入研究相关的毒性效应机制，以保证替代化学品的安全性.
    Abstract: Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) are phthalate plasticizers being widely used in plastics, resins and rubber products, which can be frequently detected in various environmental matrices. Existing studies have shown that DnBP and DiBP have significant endocrine disrupting effects and adverse effects on humans and other animals, such as reproductive and developmental toxicity. Therefore, their use is restricted in many countries and regions. As a result, some substitutive plasticizers have emerged on the market. Based on domestic and international studies on DnBP, DiBP and their substitutes, this article reviews the endocrine disrupting effects of DnBP and DiBP at individual, cellular and molecular levels, and summarizes their mechanisms of endocrine disrupting effects and their substitutive plasticizers on the market. Four typical substitutes (diisononyl phthalate, diisononyl cyclohexane-1,2-dicarboxylate, dipropylene glycol dibenzoate and glyceryl triacetate) are selected for comparative analysis of their endocrine disrupting effects. Research results show that DnBP and DiBP can affect the expression of key genes in the steroid hormone synthesis pathway at low environmental concentrations, thereby changing the level of steroid hormones in the organism. They will cause damage to the reproductive organs and ultimately reduce reproductive capacity at high concentrations, and the same effect on offspring have been reported due to the exposure during pregnancy. The four alternatives of DnBP and DiBP have reduced the acute toxicity, persistence and bioaccumulation, and endocrine disrupting effects of them have also been significantly reduced. However, there is a lack of systematic studies to fully evaluate their substitutability. It is recommended that future safety assessment of alternatives should include more toxicity endpoints and in-depth study of mechanisms of related toxic effects to ensure the safety of substitutes.
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  • [1] FOSTER P M D, CATTLEY R C, MYLCHREEST E. Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat:Implications for human risk assessment.[J]. Food & Chemical Toxicology, 2000, 38(1 Suppl):S97-S99.
    [2] BORCH J, AXELSTAD M, VINGGAARD A M, et al. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis[J]. Toxicology Letters, 2006, 163(3):183-190.
    [3] GUO Y, KANNAN K. Challenges encountered in the analysis of phthalate esters in foodstuffs and other biological matrices[J]. Analytical and Bioanalytical Chemistry, 2012, 404(9):2539-2554.
    [4] HE Y, WANG Q, HE W, et al. The occurrence, composition and partitioning of phthalate esters (PAEs) in the water-suspended particulate matter (SPM) system of Lake Chaohu, China[J]. Science of the Total Environment, 2019, 661:285-293.
    [5] HARRIS C A, HENTTU P, PARKER M G, et al. The estrogenic activity of phthalate esters in vitro[J]. Environmental Health Perspectives, 1997, 105(8):802-811.
    [6] ZENG F, CUI K, XIE Z, et al. Occurrence of phthalate esters in water and sediment of urban lakes in a subtropical city, Guangzhou, South China[J]. Environment International, 2008, 34(3):372-380.
    [7] SHI W, HU X, ZHANG F, et al. Occurrence of thyroid hormone activities in drinking water from eastern China:Contributions of phthalate esters[J]. Environmental Science & Technology, 2012, 46(3):1811-1818.
    [8] WANG Y, HU W, CAO Z, et al. Occurrence of endocrine-disrupting compounds in reclaimed water from Tianjin, China[J]. Analytical and Bioanalytical Chemistry, 2005, 383(5):857-863.
    [9] LIU H, CUI K, ZENG F, et al. Occurrence and distribution of phthalate esters in riverine sediments from the Pearl River Delta region, South China[J]. Marine Pollution Bulletin, 2014, 83(1):358-365.
    [10] PALUSELLI A, FAUVELLE V, SCHMIDT N, et al. Distribution of phthalates in Marseille Bay (NW Mediterranean Sea)[J]. Science of the Total Environment, 2018, 621:578-587.
    [11] GUERRA M T, SCARANO W R, DE TOLEDO F C, et al. Reproductive development and function of female rats exposed to di-η-butyl-phthalate (DBP) in utero and during lactation[J]. Reproductive Toxicology, 2010, 29(1):99-105.
    [12] WITTASSEK M, ANGERER J. Phthalates:Metabolism and exposure[J]. International Journal of Andrology, 2010, 31(2):131-138.
    [13] KLEINSASSER N H, KASTENBAUER E R, WALLNER B C, et al. Genotoxicity of phthalates. Are softeners in plastics hazardous to children?[J]. HNO, 2001, 49(5):378-381.
    [14] KLEINSASSER N H, WALLNER B C, KASTENBAUER E R, et al. Genotoxicity of di-butyl-phthalate and di-iso-butyl-phthalate in human lymphocytes and mucosal cells[J]. Teratogenesis, Carcinogenesis, and Mutagenesis, 2001, 21(3):189-196.
    [15] XU H, DONG X, ZHANG Z, et al. Assessment of immunotoxicity of dibutyl phthalate using live zebrafish embryos[J]. Fish & Shellfish Immunology, 2015, 45(2):286-292.
    [16] MIODOVNIK A, EDWARDS A, BELLINGER D C, et al. Developmental neurotoxicity of ortho-phthalate diesters:Review of human and experimental evidence[J]. Neurotoxicology, 2014, 41:112-122.
    [17] LI X, JIANG L, CHEN L, et al. Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure:A study in rats[J]. Environmental Toxicology and Pharmacology, 2013, 36(2):392-402.
    [18] TSENG I L, YANG Y, YU C, et al. Phthalates induce neurotoxicity affecting locomotor and thermotactic behaviors and AFD neurons through oxidative stress in Caenorhabditis elegans[J]. PLoS One, 2013, 8(12):e82657.
    [19] XU H, SHAO X, ZHANG Z, et al. Effects of di-n-butyl phthalate and diethyl phthalate on acetylcholinesterase activity and neurotoxicity related gene expression in embryonic zebrafish[J]. Bulletin of Environmental Contamination and Toxicology, 2013, 91(6):635-639.
    [20] FUJⅡ M, SHINOHARA N, LIM A, et al. A study on emission of phthalate esters from plastic materials using a passive flux sampler[J]. Atmospheric Environment, 2003, 37(39):5495-5504.
    [21] XU N, CHEN P, LIU L, et al. Effects of combined exposure to 17α-ethynylestradiol and dibutyl phthalate on the growth and reproduction of adult male zebrafish (Danio rerio)[J]. Ecotoxicology and Environmental Safety, 2014, 107:61-70.
    [22] BHATIA H, KUMAR A, OGINO Y, et al. Di-n-butyl phthalate causes estrogenic effects in adult male murray rainbowfish (Melanotaenia fluviatilis)[J]. Aquatic Toxicology, 2014, 149:103-115.
    [23] ZHANG X, QU N, ZHENG J, et al. Di (n-butyl) phthalate inhibits testosterone synthesis through a glucocorticoid-mediated pathway in rats[J]. International Journal of Toxicology, 2009, 28(5):448-456.
    [24] EMA M, MIYAWAKI E, KAWASHIMA K. Effects of dibutyl phthalate on reproductive function in pregnant and pseudopregnant rats[J]. Reproductive Toxicology, 2000, 14(1):13-19.
    [25] GRAY JR L E, LASKEY J, OSTBY J. Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats[J]. Toxicological Sciences, 2006, 93(1):189-195.
    [26] HU X, SHI W, WEI S, et al. Occurrence and potential causes of androgenic activities in source and drinking water in China[J]. Environmental Science & Technology, 2013, 47(18):10591-600.
    [27] TAKEUCHI S, ⅡDA M, KOBAYASHI S, et al. Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor[J]. Toxicology, 2005, 210(2/3):223-233.
    [28] CHEN J, WU S, TSAI S C, et al. Changes in vitellogenin and estrogen receptor expression and 17β-estradiol concentration in male juvenile tilapia can be used to evaluate endocrine-disrupting chemicals[J]. Comparative Biochemistry and Physiology Part C:Toxicology & Pharmacology, 2020, 229:108682.
    [29] CHEN H, FENG W, CHEN K, et al. Transcriptomic analysis reveals potential mechanisms of toxicity in a combined exposure to dibutyl phthalate and diisobutyl phthalate in zebrafish (Danio rerio) ovary[J]. Aquatic Toxicology, 2019, 216:105290.
    [30] HABERT R, MUCZYNSKI V, LEHRAIKi A, et al. Adverse effects of endocrine disruptors on the foetal testis development:Focus on the phthalates[J]. Folia Histochemica et Cytobiologica, 2009, 47(5):67-74.
    [31] LYCHE J L, GUTLEB A C, BERGMAN A, et al. Reproductive and developmental toxicity of phthalates[J]. Journal of Toxicology and Environmental Health, Part B, 2009, 12(4):225-249.
    [32] MARTINOANDRADE A J, CHAHOUD I. Reproductive toxicity of phthalate esters[J]. Molecular Nutrition & Food Research, 2010, 54(1):148-157.
    [33] PAN G, HANAOKA T, YU L, et al. Associations between hazard indices of di-n-butylphthalateand di-2-ethylhexylphthalate exposure and serum reproductive hormone levels among occupationally exposed and unexposed Chinese men[J]. International Journal of Andrology, 2011, 34(5pt2):e397-e406.
    [34] ZHANG Y, ZHENG L, CHEN B. Phthalate exposure and human semen quality in Shanghai:A cross-sectional study[J]. Biomedical and Environmental Sciences, 2006, 19(3):205-209.
    [35] MEEKER J D, HU H, CANTONWINE D E, et al. Urinary phthalate metabolites in relation to preterm birth in Mexico City[J]. Environmental Health Perspectives, 2009, 117(10):1587-1592.
    [36] ZHANG Y, LIN L, CAO Y, et al. Phthalate levels and low birth weight:A nested case-control study of Chinese newborns[J]. The Journal of Pediatrics, 2009, 155(4):500-504.
    [37] HUANG P, KUO P, CHOU Y, et al. Association between prenatal exposure to phthalates and the health of newborns[J]. Environment International, 2009, 35(1):14-20.
    [38] SWAN S H. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans[J]. Environmental Research, 2008, 108(2):177-184.
    [39] SWAN S H, MAIN K M, LIU F, et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure[J]. Environmental Health Perspectives, 2005, 113(8):1056-1061.
    [40] HUANG P, TSAI E, LI W, et al. Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis[J]. Human Reproduction, 2010, 25(4):986-994.
    [41] WEUVE J, HAUSER R, CALAFAT A M, et al. Association of exposure to phthalates with endometriosis and uterine leiomyomata:Findings from NHANES, 1999-2004[J]. Environmental Health Perspectives, 2010, 118(6):825-832.
    [42] HUANG Y, LI J, GARCIA J M, et al. Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women[J]. PloS One, 2014, 9(2):e87430.
    [43] WANG X, SHENG N, CUI R, et al. Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring[J]. Chemosphere, 2017, 172:260-267.
    [44] SHINSHI O, KOGO H. Effect of phthalic acid esters on mouse testes[J]. Toxicology Letters, 1980, 5(6):413-416.
    [45] ZHU X, TAY T W, ANDRIANA B B, et al. Effects of di-iso-butyl phthalate on testes of prepubertal rats and mice[J]. Okajimas Folia Anatomica Japonica, 2010, 86(4):129-136.
    [46] PAN Y, WANG X, YEUNG L W, et al. Dietary exposure to di-isobutyl phthalate increases urinary 5-methyl-2'-deoxycytidine level and affects reproductive function in adult male mice[J]. Journal of Environmental Sciences, 2017, 61:14-23.
    [47] SAILLENFAIT A M, SABATE J P, GALLISSOT F. Developmental toxic effects of diisobutyl phthalate, the methyl-branched analogue of di-n-butyl phthalate, administered by gavage to rats[J]. Toxicology Letters, 2006, 165(1):39-46.
    [48] HANNAS B R, LAMBRIGHT C S, FURR J, et al. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate[J]. Toxicological Sciences, 2011, 123(1):206-216.
    [49] SOHN J, KIM S, KOSCHORRECK J, et al. Alteration of sex hormone levels and steroidogenic pathway by several low molecular weight phthalates and their metabolites in male zebrafish (Danio rerio) and/or human adrenal cell (H295R) line[J]. Journal of Hazardous Materials, 2016, 320:45-54.
    [50] BHATIA H, KUMAR A, DU J, et al. Di-n-butyl phthalate causes antiestrogenic effects in female murray rainbowfish (Melanotaenia fluviatilis)[J]. Environmental Toxicology and Chemistry, 2013, 32(10):2335-2344.
    [51] KIM Y J, RYU J C. Evaluation of estrogenic effects of phthalate analogues using in vitro and in vivo screening assays[J]. Molecular & Cellular Toxicology, 2006, 2(2):106-113.
    [52] RYU J Y, LEE B M, KACEW S, et al. Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di(n-butyl) phthalate[J]. Toxicology, 2007, 234(1):103-112.
    [53] SEN N, LIU X, CRAIG Z R, et al. Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1 mice[J]. Reproductive Toxicology, 2015, 53:15-22.
    [54] LEHMANN K P, PHILLIPS S, SAR M, et al. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate[J]. Toxicological Sciences, 2004, 81(1):60-68.
    [55] BARLOW N J, PHILLIPS S L, WALLACE D G, et al. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate[J]. Toxicological Sciences, 2003, 73(2):431-441.
    [56] SAILLENFAIT A M, SABATE J P, DENIS F, et al. Evaluation of the effects of alpha-cypermethrin on fetal rat testicular steroidogenesis[J]. Reproductive Toxicology, 2017, 72:106-114.
    [57] PROKKOLA J M, KATSIADAKI I, SEBIRE M, et al. Microarray analysis of di-n-butyl phthalate and 17α ethinyl-oestradiol responses in three-spined stickleback testes reveals novel candidate genes for endocrine disruption[J]. Ecotoxicology and Environmental Safety, 2016, 124:96-104.
    [58] BOBERG J, METZDORFF S, WORTZIGER R, et al. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats[J]. Toxicology, 2008, 250(2/3):75-81.
    [59] GB9685-2008.《食品容器、包装材料用添加剂使用卫生标准》[S]. 北京:中国标准出版社, 2008. GB9685-2008. Hygienic standards for the use of additives for food containers and packaging materials[S]. Beijing:Standards Press of China, 2008(in Chinese).
    [60] EU 10/2011. Commission Regulation (EU) No.10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food[S]. Official Journal of the Eurpean Communities, 2011.
    [61] HUANG Y, SUN F, TAN H, et al. DEHP and DINP induce tissue-and gender-specific disturbances in fatty acid and lipidomic profiles in neonatal mice:A comparative study[J]. Environmental Science & Technology, 2019, 53(21):12812-12822.
    [62] HØIBYE L, MAAG J, HANSEN E. Background data for annex XV dossier-DEHP, BBP, DBP and DIBP[M]. Miljøstyrelsen, 2011.
    [63] BUI T T, GIOVANOULIS G, COUSINS A P, et al. Human exposure, hazard and risk of alternative plasticizers to phthalate esters[J]. Science of the Total Environment, 2016, 541:451-467.
    [64] BIEDERMANNBREM S, BIEDERMANN M, PFENNINGER S, et al. Plasticizers in PVC toys and childcare products:What succeeds the phthalates? Market survey 2007[J]. Chromatographia, 2008, 68(3/4):227-234.
    [65] MATHEW R, ARUN P, MADHAVARAO C N, et al. Progress toward acetate supplementation therapy for Canavan disease:Glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315(1):297-303.
    [66] OGAWA T, MORIWAKI N, FUJⅡ R, et al. Triacetin as food additive in gummy candy and other foodstuffs on the market[J]. The Kitasato Archives of Experimental Medicine, 1992, 65(1):33-44.
    [67] FIUME M. Final report on the safety assessment of triacetin[J]. International Journal of Toxicology, 2003, 22:1-10.
    [68] CHEN X, XU S, TAN T, et al. Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures[J]. International Journal of Environmental Research and Public Health, 2014, 11(3):3156-3168.
    [69] FORNERPIQUER I, MYLONAS C C, FAKRIADIS I, et al. Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season[J]. Archives of Toxicology, 2019, 93(3):727-741.
    [70] REVATHY V, CHITRA K. Di-isononyl phthalate (DINP) and di-(2-ethylhexyl)-phthalate (DEHP) disrupts endocrine functions in the freshwater fish, Oreochromis mossambicus (Peters, 1852)[J]. Journal of Advanced Scientific Research, 2019, 10:26-31.
    [71] SANTANGELI S, MARADONNA F, ZANARDINI M, et al. Effects of diisononyl phthalate on Danio rerio reproduction[J]. Environmental Pollution, 2017, 231(1):1051-1062.
    [72] BOBERG J, CHRISTIANSEN S, AXELSTAD M, et al. Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats[J]. Reproductive Toxicology, 2011, 31(2):200-209.
    [73] ELJEZI T, PINTA P, RICHARD D, et al. In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line[J]. Chemosphere, 2017, 173:452-459.
    [74] ENGEL A, BUHRKE T, KASPER S, et al. The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.[J]. Toxicology Letters, 2018, 287:83-91.
    [75] CAMPIOLI E, DUONG T B, DESCHAMPS F, et al. Cyclohexane-1, 2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue[J]. Environmental Research, 2015, 140:145-156.
    [76] CAMPIOLI E, LEE S, LAU M, et al. Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism[J]. Scientific Reports, 2017, 7(1):1-14.
    [77] NONE. Opinion of the scientific panel on food additives, flavorings, processing aids and materials in contact with food (AFC) on a request related to a 17th list of substances for food control materials[J]. EFSA J, 2006, 601/609:1-24.
    [78] BHAT V S, DURHAM J L, BALL G L, et al. Derivation of an oral reference dose (RfD) for the nonphthalate alternative plasticizer 1, 2-cyclohexane dicarboxylic acid, di-isononyl ester (DINCH)[J]. Journal of Toxicology and Environmental Health, Part B, 2014, 17(2):63-94.
    [79] COMI A/S. Data on manufacture, import, export, uses and releases of dibutyl phthalate(DBP) as well as information on potential aiternatives to its use[DB/OL].[2009-1-29] https://echa.europa.eu/documents/10162/6ce77be0-6c61-4e95-9241-0c262817555a.
    [80] ALBERT O, NARDELLI T C, HALES B F, et al. Identifying Greener and Safer Plasticizers:A 4-Step Approach[J]. Toxicological Sciences, 2018, 161(2):266-275.
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罗艺文, 高盼, 闫路, 张效伟, 于红霞, 史薇, 于南洋. 邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展[J]. 环境化学, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
引用本文: 罗艺文, 高盼, 闫路, 张效伟, 于红霞, 史薇, 于南洋. 邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展[J]. 环境化学, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
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LUO Yiwen, GAO Pan, YAN Lu, ZHANG Xiaowei, YU Hongxia, SHI Wei, YU Nanyang. Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes[J]. Environmental Chemistry, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
Citation: LUO Yiwen, GAO Pan, YAN Lu, ZHANG Xiaowei, YU Hongxia, SHI Wei, YU Nanyang. Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes[J]. Environmental Chemistry, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
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邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展

    通讯作者: 于南洋, E-mail: yuny@nju.edu.cn
  • 污染控制与资源化研究国家重点实验室, 南京大学环境学院, 南京, 210023
  • 收稿日期:  2020-08-06
基金项目:

国家重点研发计划（2018YFC1801604），国家自然科学基金（21922603），江苏省优秀青年科学基金（BK20170077），中央高校基本科研业务费专项资金（021114380139）和国家水污染控制与处理科技重大项目（2017ZX07202-001，2017ZX07602-002）资助.

摘要: 邻苯二甲酸二丁酯（di-n-butyl phthalate，DnBP）和邻苯二甲酸二异丁酯（diisobutyl phthalate，DiBP）是广泛用于塑料、树脂和橡胶制品中的邻苯二甲酸酯类增塑剂，曾在各种环境介质中频繁检出.现有研究表明，DnBP和DiBP对人类和其他动物具有显著的内分泌干扰效应以及生殖发育毒性等不良影响，因而在许多国家和地区被限制使用，由此市面上涌现出了一些替代品增塑剂.本文结合国内外关于DnBP和DiBP及其替代品的研究成果，综述了DnBP和DiBP在个体、细胞和分子水平上的内分泌干扰效应与机制以及在市场应用中的替代情况，并且选取了4种典型的替代品（邻苯二甲酸二异壬酯、环己烷-1，2-二羧酸二异壬酯、二苯甲酸二聚丙二醇酯、三乙酸甘油酯）对其内分泌干扰效应进行对比分析.研究结果表明，DnBP和DiBP在环境低浓度下能够影响类固醇激素合成通路中关键基因的表达，进而改变生物体内类固醇激素的水平，高浓度暴露时则会对生殖器官造成损伤并最终降低生殖能力，妊娠期暴露还会对后代产生相同的影响.DnBP和DiBP的4种替代品在急性毒性、持久性和生物可累积性方面均有所降低，内分泌干扰效应也显著降低，但缺乏系统的研究以全面评估其可替代性.提出今后替代品的安全性评估应纳入更多的毒性终点并深入研究相关的毒性效应机制，以保证替代化学品的安全性.

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