欧盟计算毒理技术政策研究及对我国新污染物治理的启示
Policy Research on Computational Toxicology in European Union and Its Implications for Emerging Pollutants Treatment in China
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摘要: 计算毒理工具正逐渐成为获取化学物质危害筛查所需数据的重要途径，是我国“十四五”期间新污染物治理的热点研究领域之一。为了借鉴发达国家计算毒理政策和管理经验，本文系统梳理了欧盟计算毒理技术相关法规政策、实施机构及计算毒理工具的开发及评估程序。研究发现，欧盟建立了一套相对完善的计算毒理工具开发和评估体系，欧盟JRC已发布QSAR模型154个，共覆盖35个预测终点5大类预测模型。本研究对于我国计算毒理政策法规体系建设以及新污染物治理中关于计算毒理工具的征集、评估和推荐等工作具有一定借鉴意义。Abstract: Computational toxicology tools are gradually becoming an important way to obtain the data needed for chemical hazard screening, which is one of the hot research fields of emerging pollutants treatment during the 14th Five-Year Plan period in China. In order to draw lessons from the policies and management experience of developed countries on computational toxicology, this paper systematically reviews the relevant regulations and policies, implementation agencies and development and evaluation procedures of computational toxicology tools in the European Union. It was found that the European Union has established a relatively complete system for the development and evaluation of computational toxicology tools. The European Union JRC has issued 154 QSAR models covering 35 endpoints and 5 categories of prediction models. This study can be used as a reference for the construction of computational toxicology policies and regulations in China and the collection, evaluation and recommendation of computational toxicology tools in the treatment of emerging pollutants.
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