多溴联苯醚在肝脏中的残留代谢及毒性作用研究进展
Research Progress in Residual Metabolism and Hepatotoxicity of Polybrominated Diphenyl Ethers (PBDEs)
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摘要: 多溴联苯醚（polybrominated diphenyl ethers，PBDEs）是一类具有亲脂性、难降解、易沉积和高生物毒性的持久性有机污染物，在全球范围常被用作添加型溴代阻燃剂。近年来，PBDEs广泛暴露于环境介质和生命体内（植物、动物、人体）内，对生态环境和人类健康造成巨大的安全风险，引起机体多个器官的毒性作用。其中肝脏是PBDEs代谢及其毒性攻击的主要靶标器官之一，已有资料证明PBDEs易积聚在肝脏中，发生氧化脱溴、还原脱溴或CYP酶介导的生物转化等。故本文围绕PBDEs在肝脏中的污染暴露、代谢转化、毒性作用及致毒机理等方面进行综述，旨在为深入探索PBDEs的肝毒性相关研究提供科学的理论依据。Abstract: Polybrominated diphenyl ethers (PBDEs) are one group of persistent organic pollutants (POPs) with the nature of high lipophilicity, difficult degradation, easy bioaccumulation and high biotoxicity, which have been widely used as an additive flame retardant all over the world. Recently, the various environmental matrices and organisms (animals and plants, and the human body) have been frequently exposed to PBDEs, and bring the huge potential risks for ecological environment and human health. Additionally, the serious toxicity of several organs is observed after exposure to PBDEs, and the liver is one of the main toxic target organs which responsible for the metabolism of PBDEs. Accumulated information demonstrated that PBDEs are easily accumulated in the liver, and can be degraded to other brominated derivatives through debrominated reductive or oxidative metabolism, and the biotransformation process is mediated by CYP enzymes. In this study, the pollution exposure, metabolic transformation, toxic effect and mechanism of PBDEs in the liver were reviewed, which is aimed to provide a scientific basis for further exploration of hepatotoxicity about PBDEs.
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Key words:
- polybrominated diphenyl ethers /
- liver toxicity /
- metabolism /
- research progress
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