BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响

庄娟, 张佳琪, 汤潇, 马心如, 张丽娅, 李梦秋. BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响[J]. 生态毒理学报, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001
引用本文: 庄娟, 张佳琪, 汤潇, 马心如, 张丽娅, 李梦秋. BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响[J]. 生态毒理学报, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001
Zhuang Juan, Zhang Jiaqi, Tang Xiao, Ma Xinru, Zhang Liya, Li Mengqiu. The Neurotoxic Effects of Chronic Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether on Mouse Parietal Cortex, Hippocampus and Thalamus Regions[J]. Asian journal of ecotoxicology, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001
Citation: Zhuang Juan, Zhang Jiaqi, Tang Xiao, Ma Xinru, Zhang Liya, Li Mengqiu. The Neurotoxic Effects of Chronic Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether on Mouse Parietal Cortex, Hippocampus and Thalamus Regions[J]. Asian journal of ecotoxicology, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001

BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响

    作者简介: 庄娟(1977-),女,博士,副教授,研究方向为环境毒理学,E-mail:dajiangsky@163.com
    通讯作者: 庄娟, E-mail: dajiangsky@163.com
  • 基金项目:

    江苏省高校自然科学基金资助项目(18KJB330001);江苏省环洪泽湖生态农业生物技术重点实验室开放基金资助项目(HZHLAB1707)

  • 中图分类号: X171.5

The Neurotoxic Effects of Chronic Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether on Mouse Parietal Cortex, Hippocampus and Thalamus Regions

    Corresponding author: Zhuang Juan, dajiangsky@163.com
  • Fund Project:
  • 摘要: 为探讨2,2',4,4'-四溴联苯醚(BDE-47)慢性暴露对脑顶叶皮质、海马和丘脑组织的影响及机制,小鼠经口腔灌胃20 mg·kg-1剂量的BDE-47,每日一次,共处理8周。检测小鼠脑相应组织的病理学变化、NLRP3表达、炎症因子IL-1βIL-6的基因表达、小胶质细胞活化及细胞凋亡情况。结果表明,BDE-47慢性暴露使小鼠顶叶皮质、海马和丘脑组织神经细胞出现排列紊乱,神经元胞体固缩以及形态不规则等细胞形态学改变;并使小鼠顶叶皮质、海马和丘脑组织的NLRP3和Iba1蛋白表达增强,炎症因子IL-1βIL-6表达增强,TUNEL信号加强。结果提示,BDE-47慢性暴露可损伤小鼠顶叶皮质、海马和丘脑组织,其毒性机制可能与NLRP3炎症小体介导的炎症反应和细胞凋亡异常增强有关。
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  • 收稿日期:  2019-06-21
庄娟, 张佳琪, 汤潇, 马心如, 张丽娅, 李梦秋. BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响[J]. 生态毒理学报, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001
引用本文: 庄娟, 张佳琪, 汤潇, 马心如, 张丽娅, 李梦秋. BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响[J]. 生态毒理学报, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001
Zhuang Juan, Zhang Jiaqi, Tang Xiao, Ma Xinru, Zhang Liya, Li Mengqiu. The Neurotoxic Effects of Chronic Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether on Mouse Parietal Cortex, Hippocampus and Thalamus Regions[J]. Asian journal of ecotoxicology, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001
Citation: Zhuang Juan, Zhang Jiaqi, Tang Xiao, Ma Xinru, Zhang Liya, Li Mengqiu. The Neurotoxic Effects of Chronic Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether on Mouse Parietal Cortex, Hippocampus and Thalamus Regions[J]. Asian journal of ecotoxicology, 2020, 15(5): 228-234. doi: 10.7524/AJE.1673-5897.20190621001

BDE-47慢性暴露对小鼠顶叶皮质、海马和丘脑的影响

    通讯作者: 庄娟, E-mail: dajiangsky@163.com
    作者简介: 庄娟(1977-),女,博士,副教授,研究方向为环境毒理学,E-mail:dajiangsky@163.com
  • 1. 江苏省高校区域现代农业与环境保护协同创新中心, 淮阴师范学院, 淮安 223300;
  • 2. 江苏省环洪泽湖生态农业生物技术重点实验室, 淮阴师范学院生命科学学院, 淮安 223300;
  • 3. 江苏省药用植物生物技术重点实验室, 江苏师范大学, 徐州 221116
基金项目:

江苏省高校自然科学基金资助项目(18KJB330001);江苏省环洪泽湖生态农业生物技术重点实验室开放基金资助项目(HZHLAB1707)

摘要: 为探讨2,2',4,4'-四溴联苯醚(BDE-47)慢性暴露对脑顶叶皮质、海马和丘脑组织的影响及机制,小鼠经口腔灌胃20 mg·kg-1剂量的BDE-47,每日一次,共处理8周。检测小鼠脑相应组织的病理学变化、NLRP3表达、炎症因子IL-1βIL-6的基因表达、小胶质细胞活化及细胞凋亡情况。结果表明,BDE-47慢性暴露使小鼠顶叶皮质、海马和丘脑组织神经细胞出现排列紊乱,神经元胞体固缩以及形态不规则等细胞形态学改变;并使小鼠顶叶皮质、海马和丘脑组织的NLRP3和Iba1蛋白表达增强,炎症因子IL-1βIL-6表达增强,TUNEL信号加强。结果提示,BDE-47慢性暴露可损伤小鼠顶叶皮质、海马和丘脑组织,其毒性机制可能与NLRP3炎症小体介导的炎症反应和细胞凋亡异常增强有关。

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