2019 Volume 14 Issue 5
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Xue Ke, Xu Xia, Xue Yingang, Mu Yunsong, Liu Fei, Jiang Xiaodong, Shi Xinlan, Gu Ming. Research Progress of Life-cycle Toxicity Test of Zebrafish[J]. Asian Journal of Ecotoxicology, 2019, 14(5): 83-96. doi: 10.7524/AJE.1673-5897.20181011002
Citation: Xue Ke, Xu Xia, Xue Yingang, Mu Yunsong, Liu Fei, Jiang Xiaodong, Shi Xinlan, Gu Ming. Research Progress of Life-cycle Toxicity Test of Zebrafish[J]. Asian Journal of Ecotoxicology, 2019, 14(5): 83-96. doi: 10.7524/AJE.1673-5897.20181011002
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Research Progress of Life-cycle Toxicity Test of Zebrafish

  • 1. School of Environmental and Safety Engineering, Changzhou University, Changzhou 213164, China;

  • 2. Key Laboratory of Environmental Protection of Water Environment Biological Monitoring of Jiangsu Province, Changzhou Environmental Monitoring Center, Changzhou 213001, China;

  • 3. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China;

  • 4. College of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, China

  • Corresponding authors: Xue Yingang, yzxyg@126.com ;  Mu Yunsong, muys@craes.org.cn ; 
  • Received Date: 11/10/2018
    Accepted Date: 10/01/2019
    Fund Project:
  • As a model organism, zebrafish (Danio rerio) is widely used in ecotoxicology and other fields as its small size, low cost, wide adaptability, short breeding cycle, high fertility and embryonic transparency. The life stage of zebrafish mainly includes embryo, larvae and adult. The proportion of toxicology research of zebrafish life cycle continued to rise and showed a steady growth trend in recent years. In present study, the toxicity tests of zebrafish in three life stages and the whole life cycle was introduced and reviewed. Secondly, toxicity test guideline and standard of zebrafish in various life stages, resource library information, endpoint and transgenic zebrafish were also summarized. Thirdly, the application of multi-stage and whole life cycle toxicity assessment were generalized. Finally, the prospects of the application of zebrafish toxicity testing and the whole life cycle were discussed and suggested in future research.
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Research Progress of Life-cycle Toxicity Test of Zebrafish

  • Received Date: 11/10/2018
  • Accepted Date: 10/01/2019
Fund Project:

Abstract: As a model organism, zebrafish (Danio rerio) is widely used in ecotoxicology and other fields as its small size, low cost, wide adaptability, short breeding cycle, high fertility and embryonic transparency. The life stage of zebrafish mainly includes embryo, larvae and adult. The proportion of toxicology research of zebrafish life cycle continued to rise and showed a steady growth trend in recent years. In present study, the toxicity tests of zebrafish in three life stages and the whole life cycle was introduced and reviewed. Secondly, toxicity test guideline and standard of zebrafish in various life stages, resource library information, endpoint and transgenic zebrafish were also summarized. Thirdly, the application of multi-stage and whole life cycle toxicity assessment were generalized. Finally, the prospects of the application of zebrafish toxicity testing and the whole life cycle were discussed and suggested in future research.

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