三种药品联合毒性作用及其环境风险分析

董玉瑛; 邹学军; 陈峥; 丁玲

doi:10.7524/j.issn.0254-6108.2013.07.019

环境化学

三种药品联合毒性作用及其环境风险分析

, , ,

董玉瑛, 邹学军, 陈峥, 丁玲. 三种药品联合毒性作用及其环境风险分析[J]. 环境化学, 2013, 32(7): 1257-1262. doi: 10.7524/j.issn.0254-6108.2013.07.019

引用本文:

董玉瑛, 邹学军, 陈峥, 丁玲. 三种药品联合毒性作用及其环境风险分析[J]. 环境化学, 2013, 32(7): 1257-1262. doi: 10.7524/j.issn.0254-6108.2013.07.019

DONG Yuying, ZOU Xuejun, CHEN Zheng, DING Ling. Joint toxicity and environmental risk analysis of three common pharmaceuticals[J]. Environmental Chemistry, 2013, 32(7): 1257-1262. doi: 10.7524/j.issn.0254-6108.2013.07.019

Citation:

DONG Yuying, ZOU Xuejun, CHEN Zheng, DING Ling. Joint toxicity and environmental risk analysis of three common pharmaceuticals[J]. Environmental Chemistry, 2013, 32(7): 1257-1262. doi: 10.7524/j.issn.0254-6108.2013.07.019

三种药品联合毒性作用及其环境风险分析

1.
大连民族学院环境科学与工程系, 大连, 116605
基金项目:
国家自然科学基金项目(21077022)

辽宁省教育厅高等学校科研项目计划(L2010100)资助.

Joint toxicity and environmental risk analysis of three common pharmaceuticals

1.
Department of Environmental Science and Technology, Dalian Nationalities University, Dalian, 116605, China
Fund Project:

摘要: 测定了阿司匹林、盐酸环丙沙星和阿奇霉素3种常见活性医药成分(APIs)对发光菌的单一毒性以及混合体系的联合毒性,并应用毒性单位法(TU)、相加指数法(AI)和混合毒性指数(MTI)等方法对混合体系联合作用类型进行分析.结果表明,阿司匹林显示较高的单一毒性,联合毒性中除阿司匹林-环丙沙星二元混合体系为部分相加作用外,其它体系联合毒性均呈现为不同程度的拮抗作用.同时应用简化环境模型计算了3种医药品的预测环境浓度(PEC)和预测无效应浓度(PNEC),将风险表征参数(PEC/PNEC)作为综合评价因子,获得3种医药品目前在大连开发区污水处理厂排水中的数值较低,以阿司匹林综合评价因子最高.
- 活性医药成分(APIs) /
- 发光菌 /
- 联合毒性 /
- 综合评价因子 /
- 风险分析
Abstract: Single and joint toxicity of three active pharmaceutical ingredients (APIs), aspirin, ciprofloxacin hydrochloride and azithromycin, were determined by applying the toxicity test to Photobacterium phosphoreum.The modes of joint toxicity for the binary mixture and ternary mixture of the three APIs were analyzed by toxic unit method (TU), additive index method (AI) and mixed toxicity index (MTI). The results showed that aspirin had the highest single toxicity. The joint action of aspirin and ciprofloxacin hydrochloride was partly additive, and the other mixtures were antagonistic. Based on related models, predicted environmental concentration (PEC) and predicted no-effect concentration (PNEC) of the three antibiotics in the effluent from sewage treatment plants in Dalian Developed Zone were obtained. Risk characterization parameter (PEC/PNEC) was used as a comprehensive assessment factor. It was concluded that the current residual levels of 3 pharmaceuticals were acceptable, though aspirin showed highest risk among them.
- active pharmaceutical ingredients (APIs) /
- Photobacteriun phosphoreum /
- joint toxicity /
- comprehensive assessment factors /
- risk analysis

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董玉瑛, 邹学军, 陈峥, 丁玲. 三种药品联合毒性作用及其环境风险分析[J]. 环境化学, 2013, 32(7): 1257-1262. doi: 10.7524/j.issn.0254-6108.2013.07.019

引用本文:

董玉瑛, 邹学军, 陈峥, 丁玲. 三种药品联合毒性作用及其环境风险分析[J]. 环境化学, 2013, 32(7): 1257-1262. doi: 10.7524/j.issn.0254-6108.2013.07.019

Citation:

三种药品联合毒性作用及其环境风险分析

1. 大连民族学院环境科学与工程系, 大连, 116605

收稿日期: 2013-02-28

基金项目:

国家自然科学基金项目(21077022)

辽宁省教育厅高等学校科研项目计划(L2010100)资助.

关键词:

摘要: 测定了阿司匹林、盐酸环丙沙星和阿奇霉素3种常见活性医药成分(APIs)对发光菌的单一毒性以及混合体系的联合毒性,并应用毒性单位法(TU)、相加指数法(AI)和混合毒性指数(MTI)等方法对混合体系联合作用类型进行分析.结果表明,阿司匹林显示较高的单一毒性,联合毒性中除阿司匹林-环丙沙星二元混合体系为部分相加作用外,其它体系联合毒性均呈现为不同程度的拮抗作用.同时应用简化环境模型计算了3种医药品的预测环境浓度(PEC)和预测无效应浓度(PNEC),将风险表征参数(PEC/PNEC)作为综合评价因子,获得3种医药品目前在大连开发区污水处理厂排水中的数值较低,以阿司匹林综合评价因子最高.

English Abstract

Joint toxicity and environmental risk analysis of three common pharmaceuticals

1. Department of Environmental Science and Technology, Dalian Nationalities University, Dalian, 116605, China

Received Date: 2013-02-28

Fund Project:

Keywords:

active pharmaceutical ingredients (APIs) /
Photobacteriun phosphoreum /
joint toxicity /
comprehensive assessment factors /
risk analysis

Abstract: Single and joint toxicity of three active pharmaceutical ingredients (APIs), aspirin, ciprofloxacin hydrochloride and azithromycin, were determined by applying the toxicity test to Photobacterium phosphoreum.The modes of joint toxicity for the binary mixture and ternary mixture of the three APIs were analyzed by toxic unit method (TU), additive index method (AI) and mixed toxicity index (MTI). The results showed that aspirin had the highest single toxicity. The joint action of aspirin and ciprofloxacin hydrochloride was partly additive, and the other mixtures were antagonistic. Based on related models, predicted environmental concentration (PEC) and predicted no-effect concentration (PNEC) of the three antibiotics in the effluent from sewage treatment plants in Dalian Developed Zone were obtained. Risk characterization parameter (PEC/PNEC) was used as a comprehensive assessment factor. It was concluded that the current residual levels of 3 pharmaceuticals were acceptable, though aspirin showed highest risk among them.

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三种药品联合毒性作用及其环境风险分析

Joint toxicity and environmental risk analysis of three common pharmaceuticals

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三种药品联合毒性作用及其环境风险分析

English Abstract

Joint toxicity and environmental risk analysis of three common pharmaceuticals

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