苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究

陆光华; 袁星; 赵元慧

环境化学

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陆光华, 袁星, 赵元慧. 苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究[J]. 环境化学, 2000, 19(3): 225-229.

引用本文:

陆光华, 袁星, 赵元慧. 苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究[J]. 环境化学, 2000, 19(3): 225-229.

La Guanghua, Yuan Xing, Zhao Yuanhui. THE ACUTE TOXICITY OF ANILINE, PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY[J]. Environmental Chemistry, 2000, 19(3): 225-229.

Citation:

La Guanghua, Yuan Xing, Zhao Yuanhui. THE ACUTE TOXICITY OF ANILINE, PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY[J]. Environmental Chemistry, 2000, 19(3): 225-229.

苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究

1.
东北师范大学环境科学系, 长春, 130024
基金项目:
国家自然科学基金资助项目:No.29877004

THE ACUTE TOXICITY OF ANILINE, PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY

1.
Department of Environmental Science, Northeast Normal University, Changchun, 130024
Fund Project:

摘要: 本文应用OECD标准方法测定了18种酚类、胺类化合物对斜生栅列藻的48h-EC50值.选择参数ELUMO和lgKOW进行了QSAR分析,得到下列回归方程:-lgEC50=2.541-0.649ELUMO+0.299lgKOW,n=18,r=0.903,SE=0.314应用所得方程计算了化合物的毒性,探讨了毒性机理.
- 苯酚 /
- 苯胺 /
- 斜生栅列藻 /
- 毒性 /
- QSAR
Abstract: 50% effective inhibition concentration 48h-EC50 values of 18 aniline and phenol derivatives to Scenedesmus obliquus were measured . The qualitative structure-activity relationship (QSAR) studies were performed with the toxicity and 2 parameters of ELUMO and lgKOW. Satisfactory equation was developed as follow:-IgEC50 = 2.503-0.649ELUMO+ 0.2991lgKow n=18 r= 0.903 SE= 0.314.The QASR model was used to estimate the toxicities and discussed the intoxication mechanism.
- aniline /
- phenol /
- Scenedesmus obliquus /
- toxicity /
- QSAR

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苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究

1. 东北师范大学环境科学系, 长春, 130024

收稿日期: 1999-07-11

基金项目:

国家自然科学基金资助项目:No.29877004

关键词:

苯酚 /
苯胺 /
斜生栅列藻 /
毒性 /
QSAR

摘要: 本文应用OECD标准方法测定了18种酚类、胺类化合物对斜生栅列藻的48h-EC50值.选择参数ELUMO和lgKOW进行了QSAR分析,得到下列回归方程:-lgEC50=2.541-0.649ELUMO+0.299lgKOW,n=18,r=0.903,SE=0.314应用所得方程计算了化合物的毒性,探讨了毒性机理.

English Abstract

THE ACUTE TOXICITY OF ANILINE, PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY

1. Department of Environmental Science, Northeast Normal University, Changchun, 130024

Received Date: 1999-07-11

Fund Project:

Keywords:

Abstract: 50% effective inhibition concentration 48h-EC50 values of 18 aniline and phenol derivatives to Scenedesmus obliquus were measured . The qualitative structure-activity relationship (QSAR) studies were performed with the toxicity and 2 parameters of ELUMO and lgKOW. Satisfactory equation was developed as follow:-IgEC50 = 2.503-0.649ELUMO+ 0.2991lgKow n=18 r= 0.903 SE= 0.314.The QASR model was used to estimate the toxicities and discussed the intoxication mechanism.

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苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究

THE ACUTE TOXICITY OF ANILINE, PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY

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苯酚、苯胺及其衍生物对斜生栅列藻的急性毒性及QSAR研究

English Abstract

THE ACUTE TOXICITY OF ANILINE, PHENOL DERIVATIVES TO THE SCENEDESMUS OBLIQUUS AND QSAR STUDY

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