中药中汞的形态分析方法、生物有效性与毒性效应研究

张雨, 史建波, 何滨. 中药中汞的形态分析方法、生物有效性与毒性效应研究[J]. 环境化学, 2011, 30(7): 1322-1326.
引用本文: 张雨, 史建波, 何滨. 中药中汞的形态分析方法、生物有效性与毒性效应研究[J]. 环境化学, 2011, 30(7): 1322-1326.
ZHANG Yu, SHI Jianbo, HE Bin. SPECIATION, BIOAVAILABILITY AND TOXICITY OF MERCURY IN TRADITIONAL CHINESE MEDICINE[J]. Environmental Chemistry, 2011, 30(7): 1322-1326.
Citation: ZHANG Yu, SHI Jianbo, HE Bin. SPECIATION, BIOAVAILABILITY AND TOXICITY OF MERCURY IN TRADITIONAL CHINESE MEDICINE[J]. Environmental Chemistry, 2011, 30(7): 1322-1326.

中药中汞的形态分析方法、生物有效性与毒性效应研究

  • 基金项目:

    国家自然科学基金项目(21075130

    20807047)资助.

SPECIATION, BIOAVAILABILITY AND TOXICITY OF MERCURY IN TRADITIONAL CHINESE MEDICINE

  • Fund Project:
  • 摘要: 朱砂作为许多传统中药的有效成分,在我国已有数千年的应用历史.然而,这些中药中超标的汞含量已成为近年来中药出口的最大壁垒.研究中药中汞的赋存形态及不同形态的毒性效应和生物有效性,有助于辩证地理解中药中汞含量与毒性效应的关系,为科学地制定中药中汞的限量标准提供有力的依据.
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  • [1] Jiang G B, Ni Z M, Wang S R, et al. Determination of organomercurials in air by gas chromatography atomic absorption spectrometry[J]. Journal of Analytical Atomic Spectrometry, 1989, 4(4): 315-318
    [2] Jiang G B, Ni Z M, Wang S R, et al. Organic mercury speciation in fish by capillary gas-chromatography interfaced with atomic-absorption spectrometry[J]. Fresenius Zeitschrift Fur Analytische Chemie, 1989, 334(1): 27-30
    [3] 史建波,廖春阳,王亚韡,等. 气相色谱和原子荧光联用测定生物和沉积物样品中甲基汞[J]. 光谱学与光谱分析,2006,26:336-339
    [4] Carrasco L, Diez S, Bayona J M. Simultaneous determination of methyl- and ethyl-mercury by solid-phase microextraction followed by gas chromatography atomic fluorescence detection [J]. Journal of Chromatography A, 2009, 1216(51): 8828-8834
    [5] Chung S W C, Chan B T P. A reliable method to determine methylmercury and ethylmercury simultaneously in foods by gas chromatography with inductively coupled plasma mass spectrometry after enzymatic and acid digestion[J]. Journal of Chromatography A, 2011, 1218(9): 1260-1265
    [6] Liang L N, Jiang G B, Liu J F, et al. Speciation analysis of mercury in seafood by using high-performance liquid chromatography on-line coupled with cold-vapor atomic fluorescence spectrometry via a post column microwave digestion [J]. Analytica Chimica Acta, 2003, 477(1): 131-137
    [7] Morton J, Carolan V A, Gardiner P H E. The speciation of inorganic and methylmercury in human hair by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry [J]. Journal of Analytical Atomic Spectrometry, 2002, 17(4): 377-381
    [8] Yan X P, Yin X B, Jiang D Q, et al. Speciation of mercury by hydrostatically modified electroosmotic flow capillary electrophoresis coupled with volatile species generation atomic fluorescence spectrometry [J]. Analytical Chemistry, 2003, 75(7): 1726-1732
    [9] 锺寰, 王文雄. 沉积物中汞的生物可利用性研究进展[J]. 环境化学, 2011, 30(1): 165-178
    [10] Lawrence A L, Mcaloon K M, Mason R P, et al. Intestinal solubilization of particle-associated organic and inorganic mercury as a measure of bioavailability to benthic invertebrates [J]. Environmental Science & Technology, 1999, 33(11): 1871-1876
    [11] Chen Z, Mayer L M, Quetel C, et al. High concentrations of complexed metals in the guts of deposit feeders [J]. Limnology and Oceanography, 2000, 45(6): 1358-1367
    [12] Turner A. Enzymatic mobilisation of trace metals from estuarine sediment [J]. Marine Chemistry, 2006, 98(2/4): 140-147
    [13] Gray J E, Plumlee G S, Morman S A, et al. In vitro studies evaluating leaching of mercury from mine waste calcine using simulated human body fluids [J]. Environmental Science & Technology, 2010, 44(12): 4782-4788
    [14] 庞京团, 胡广林, 韩彬,等. 复方芦荟胶囊配伍药物对朱砂中汞生物利用性影响的研究[J]. 时珍国医国药, 2009, (12): 3082-3083
    [15] Smith R G, Vorwald A J, Patil L S, et al. Effects of exposure to mercury in manufacture of chlorine [J]. American Industrial Hygiene Association Journal, 1970, 31(6): 687-700
    [16] United Nations Environment Programme. Global mercury assessment. 2002
    [17] Harada M. Minamata disease-methylmercury poisoning in Japan caused by environmental-pollution [J]. Critical Reviews in Toxicology, 1995, 25(1): 1-24
    [18] 谭河清, 廖舰. 误服含甘汞中药致周围神经损害1例报告[J]. 中国工业医学杂志, 2003, (5): 288-289
    [19] 王艳, 杨素峰. 中药偏方致汞毒性脑病1例报告[J]. 中国工业医学杂志, 1997, (6): 19
    [20] 王悦, 苏丹颖, 石冬梅. 中药偏方致汞、铅、砷中毒12例临床误诊分析[J]. 中国工业医学杂志, 2001, (3): 151-152
    [21] Lu Y F, Yan J W, Wu Q, et al. Realgar- and cinnabar-containing An-Gong-Niu-Huang Wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride [J]. Chemico-Biological Interactions, 2011, 189(1/2): 134-140
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  • 收稿日期:  2011-07-08
张雨, 史建波, 何滨. 中药中汞的形态分析方法、生物有效性与毒性效应研究[J]. 环境化学, 2011, 30(7): 1322-1326.
引用本文: 张雨, 史建波, 何滨. 中药中汞的形态分析方法、生物有效性与毒性效应研究[J]. 环境化学, 2011, 30(7): 1322-1326.
ZHANG Yu, SHI Jianbo, HE Bin. SPECIATION, BIOAVAILABILITY AND TOXICITY OF MERCURY IN TRADITIONAL CHINESE MEDICINE[J]. Environmental Chemistry, 2011, 30(7): 1322-1326.
Citation: ZHANG Yu, SHI Jianbo, HE Bin. SPECIATION, BIOAVAILABILITY AND TOXICITY OF MERCURY IN TRADITIONAL CHINESE MEDICINE[J]. Environmental Chemistry, 2011, 30(7): 1322-1326.

中药中汞的形态分析方法、生物有效性与毒性效应研究

  • 1.  中国中医科学院望京医院, 北京, 100102;
  • 2.  中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 北京, 100085
基金项目:

国家自然科学基金项目(21075130

20807047)资助.

摘要: 朱砂作为许多传统中药的有效成分,在我国已有数千年的应用历史.然而,这些中药中超标的汞含量已成为近年来中药出口的最大壁垒.研究中药中汞的赋存形态及不同形态的毒性效应和生物有效性,有助于辩证地理解中药中汞含量与毒性效应的关系,为科学地制定中药中汞的限量标准提供有力的依据.

English Abstract

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