大气细颗粒物生殖毒性研究进展
Reproductive Toxicity of Fine Particulate Matters and Its Mechanism
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摘要: 大气污染已经成为中国最主要的污染问题。大气细颗粒物作为大气污染的主要成分，具有生殖毒性。本文总结了大气细颗粒物生殖毒性的流行病调查及其动物实验结果，并主要从氧化应激、DNA损伤、炎症反应和血睾屏障的完整性破坏等方面，归纳了近年来大气细颗粒物生殖毒性作用机制的研究成果，对现有研究中存在的问题进行了探讨，这有助于深入推进大气细颗粒物的生殖毒性研究。Abstract: The air pollution has become the main pollution problem of China. As the main component of air pollution, fine particulate matters have been shown by many studies to have toxic effects on reproductive system. This paper summarizes the epidemiological investigation and animal experiment results on the reproductive toxicity of fine particulate matters, which mainly focus on the reproductive toxicity of fine particulate matters mediated by oxidative stress, DNA damage, inflammatory response and the disruption of the integrity of blood-testis barrier. This review also discusses the existing problems of current study in order to help to promote the research on reproductive toxic effects of fine particulate matters.
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Key words:
- fine particulate matter /
- PM2.5 /
- reproductive toxicity /
- health effects /
- mechanisms
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