基于不同毒性终点的双酚A(BPA)预测无效应浓度(PNEC)研究
Predicted No Effect Concentration of Bisphenol A (BPA) Based on Different Toxicological Endpoints
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摘要: 双酚A (BPA)已被证实是一种类雌激素类物质。本研究根据BPA对水生生物毒性效应的特点,按照不同的毒性终点将BPA的毒性数据进行归类,采用物种敏感度分布法(species sensitivity distribution,SSD)推导了BPA对水生生物的预测无效应浓度(predicted no effect concentration,PNEC)。结果表明:以雌激素效应为暴露终点的急、慢性PNEC分别为25.11 μg·L-1、1.075 μg·L-1;而以所有数据的急、慢性毒性效应为暴露终点推导的PNEC值分别为355.7 μg·L-1、7.549 μg·L-1。BPA对水生生物的雌激素效应更为敏感,建议在推导BPA这类内分泌干扰物的PNEC值时,应依据其毒性终点分别推导,从而得到更加合理的基准值。研究成果以期为我国地表水环境质量标准的制修订提供数据支持。
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关键词:
- 双酚 A /
- 淡水生物 /
- 雌激素效应 /
- 内分泌干扰 /
- 预测无效应浓度(PNEC)
Abstract: Bisphenol A (BPA) has been confirmed to be an endocrine disrupting chemical. In the present study, the BPA toxicity data were classified based on different toxicological endpoints. Then, the acute and chronic PNEC (predicted no effect concentration) for protecting aquatic life were derived by use of species sensitivity distribution approach. The results showed that the acute and chronic PNECs of BPA derived from the estrogen effect data were 25.11 μg·L-1 and 1.075 μg·L-1, respectively; while for all the toxicity data, the corresponding PNECs were 355.7 μg·L-1 and 7.549 μg·L-1, respectively. Therefore, estrogen effects of BPA to organism were more sensitive than other effects. It is recommended that the PNECs for endocrine disrupting chemicals should be derived based on different toxicological endpoints. The results in the present study could provide data support for the establishment and revision of water quality standard in China.-
Key words:
- Bisphenol A (BPA) /
- freshwater organism /
- estrogen effect /
- endocrine disruption /
- PNEC
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